ArticleJournal of the American Chemical Society2017
Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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89 citing papers in PubMed, 349 citations in OpenAlex.
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- Heterobenzyl Chlorides as Linchpins for C-H Arylation via Sequential C-H Chlorination/Cross-Electrophile Coupling.ACS catalysis · 2026Article
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- α-Amido Sulfonium Salts Provide a Platform for Photocatalytic Metal-Free Carbon-Carbon Bond Formation in Amides.ACS catalysis · 2025Article
- Heterocyclic Assembly: An Underutilized Disconnection with Potential to Maximize High FspACS medicinal chemistry letters · 2025Article
- Low-energy photoredox catalysis.Nature reviews. Chemistry · 2025Review
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- Reductive deaminative cross-coupling of alkyl bistriflimides enabled by electrocatalysis.Science advances · 2024Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with an unactivated alkyl group. This reaction enjoys broad scope and functional group tolerance. Primary and secondary alkyl groups can be installed. Preliminary studies suggest a Ni
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