Evidence map›Paper›PMID 28359017›Full record

ArticleComprehensive psychiatry2017

An investigation of doubt in obsessive-compulsive disorder.

Jack Samuels, O Joseph Bienvenu, Janice Krasnow, Ying Wang, Marco A Grados, Bernadette Cullen, Fernando S Goes, Brion Maher, Benjamin D Greenberg, Nicole C McLaughlin and 15 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 2 countries.

Jack SamuelsDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jacks@jhmi.edu.
O Joseph BienvenuDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Janice KrasnowDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ying WangDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marco A GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bernadette CullenDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brion MaherDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Benjamin D GreenbergDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.
Nicole C McLaughlinDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.
Steven A RasmussenDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.
Abby J FyerDepartment of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, New York City, New York, USA.
James A KnowlesDepartment of Psychiatry, University of Southern California School of Medicine, Los Angeles, California, USA.
Paul NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James T McCrackenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA.
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA.
Dan GellerDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
David L PaulsDepartment of Psychiatry and Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
S Evelyn StewartDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver.
Dennis L MurphyLaboratory of Clinical Science, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
Yin-Yao ShugartUnit of Statistical Genomics, Division of Intramural Research, National Institute of Mental Health, Bethesda, MD, USA.
Vidya KamathDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mark A RiddleDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gerald NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USProvidence College · USNational Institute of Mental Health · USUniversity of California, Los Angeles · USColumbia University · USHarvard University · USMassachusetts General Hospital · USUniversity of British Columbia · CAUniversity of Southern California · US

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
PSYCHIATRIC EPIDEMIOLOGY TRAINING PROGRAMT32MH014592 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HEATHER E VOLK, Peter P. Zandi · 1985 to 2026
$8.5M
FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDERR01MH050214 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 1995 to 2005
$6.6M
OCD Collaborative Genetics Association StudyR01MH071507 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 2007 to 2010
$6.5M
Obsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079489 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI GELLER, DANIEL A · 2007 to 2010
$3.4M
OCD Collaborative Genetics Association StudyR01MH079488 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FYER, ABBY J · 2007 to 2010
$906k
Statistical Genomics and Data Analysis CoreZIAMH002965 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI YAO, YIN · 2017 to 2017
$856k
Obsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079494 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KNOWLES, JAMES A · 2007 to 2011
$840k
Personality, anxiety, and depression in community adultsK23MH064543 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BIENVENU, O. JOSEPH · 2003 to 2007
$839k
OCD Collaborative Genetics Association StudyR01MH079487 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2007 to 2010
$797k
Statistical Genomics and Data Analysis CoreZICMH002965 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHUGART, YIN · 2018 to 2018
$765k
NCRR NIH HHS M01 RR000052NIMH NIH HHS K23 MH064543NIMH NIH HHS R01 MH050214NIMH NIH HHS R01 MH071507NIMH NIH HHS R01 MH079487NIMH NIH HHS R01 MH079488NIMH NIH HHS R01 MH079489NIMH NIH HHS R01 MH079494NIMH NIH HHS T32 MH014592
6 · The paper itself

Abstract

backgroundClinicians have long considered doubt to be a fundamental characteristic of obsessive-compulsive disorder (OCD). However, the clinical relevance of doubt in OCD has not been addressed.

methodsParticipants included 1182 adults with OCD who had participated in family and genetic studies of OCD. We used a clinical measure of the severity of doubt, categorized as none, mild, moderate, severe, or extreme. We evaluated the relationship between doubt and OCD clinical features, Axis I disorders, personality and personality disorder dimensions, impairment, and treatment response.

resultsThe severity of doubt was inversely related to the age at onset of OCD symptoms. Doubt was strongly related to the number of checking symptoms and, to a lesser extent, to the numbers of contamination/cleaning and hoarding symptoms. Doubt also was related to the lifetime prevalence of recurrent major depression and generalized anxiety disorder; to the numbers of avoidant, dependent, and obsessive-compulsive personality disorder traits; and to neuroticism and introversion. Moreover, doubt was strongly associated with global impairment and poor response to cognitive behavioral treatment (CBT), even adjusting for OCD severity and other correlates of doubt.

conclusionsDoubt is associated with important clinical features of OCD, including impairment and cognitive-behavioral treatment response.

Indexed as

EmotionsAdolescentAdultAgedAged, 80 and overAge of OnsetAnxiety DisordersCognitive Behavioral TherapyCompulsive Personality DisorderFemaleHumansMajor Depressive DisorderMaleMiddle AgedNeuroticismObsessive-Compulsive Disorder

Identifiers

PMID28359017
PMCPMC5479326
OpenAlexW2594763689

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.