Evidence map›Paper›PMID 28358586›Full record

ReviewPlatelets2017

Utility of microfluidic devices to study the platelet-endothelium interface.

Jevgenia Zilberman-Rudenko, Joanna L Sylman, Kathleen S Garland, Cristina Puy, Andrew D Wong, Peter C Searson, Owen J T McCarty

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Platelets, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Engineering approaches for cardiac organoid formation and their characterization.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jevgenia Zilberman-Rudenkoa Biomedical Engineering, School of Medicine , Oregon Health and Science University , Portland , OR , USA.ORCID http://orcid.org/0000-0001-9862-9285
Joanna L Sylmana Biomedical Engineering, School of Medicine , Oregon Health and Science University , Portland , OR , USA.
Kathleen S Garlanda Biomedical Engineering, School of Medicine , Oregon Health and Science University , Portland , OR , USA.
Cristina Puya Biomedical Engineering, School of Medicine , Oregon Health and Science University , Portland , OR , USA.
Andrew D Wongb Institute for Nanobiotechnology (INBT) , Johns Hopkins University , Baltimore , MD , USA.
Peter C Searsonb Institute for Nanobiotechnology (INBT) , Johns Hopkins University , Baltimore , MD , USA.
Owen J T McCartya Biomedical Engineering, School of Medicine , Oregon Health and Science University , Portland , OR , USA.
Oregon Health & Science University · USJohns Hopkins University · US

Funding

Characterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Owen J McCarty · 2010 to 2026
$8.5M
FXI and SepsisR01GM116184 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LUPU, FLOREA, MCCARTY, OWEN J · 2015 to 2018
$1.9M
Role of FXI in Thrombohemorrhagic ComplicationsF31HL136230 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ZILBERMAN-RUDENKO, JEVGENIA · 2017 to 2020
$161k
NHLBI NIH HHS F31 HL136230NHLBI NIH HHS R01 HL101972NIGMS NIH HHS R01 GM116184
6 · The paper itself

Abstract

The integration of biomaterials and understanding of vascular biology has led to the development of perfusable endothelialized flow models, which have been used as valuable tools to study the platelet-endothelium interface under shear. In these models, the parameters of geometry, compliance, biorheology, and cellular complexity are varied to recapitulate the physical biology of platelet recruitment and activation under physiologically relevant conditions of blood flow. In this review, we summarize the mechanistic insights learned from perfusable microvessel models and discuss the potential utility as well as challenges of endothelialized microfluidic devices to study platelet function in the bloodstream in vitro.

Indexed as

Lab-On-A-Chip DevicesModels, CardiovascularPlatelet ActivationAnimalsBlood Flow VelocityBlood PlateletsEndothelium, VascularHumansMicrofluidic Analytical TechniquesMicrovesselsEndothelial cellshearvessel barrierVWF

Identifiers

PMID28358586
PMCPMC5678926
OpenAlexW2600621312

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.