ArticleScientific reports2017
MicroRNA exocytosis by large dense-core vesicle fusion.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- CaScience advances · 2025Article
- Review
- Case Report: Micro-RNAs in Plasma From Bilateral Inferior Petrosal Sinus Sampling and Peripheral Blood From Corticotroph Pituitary Neuroendocrine Tumors.Frontiers in endocrinology · 2022Article
- The circulatory small non-coding RNA landscape in community-acquired pneumonia on intensive care unit admission.Journal of cellular and molecular medicine · 2021Article
- Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies.Scientific reports · 2020Article
- Accurate Adapter Information Is Crucial for Reproducibility and Reusability in Small RNA Seq Studies.Non-coding RNA · 2019Article
- Costorage of High Molecular Weight Neurotransmitters in Large Dense Core Vesicles of Mammalian Neurons.Frontiers in cellular neuroscience · 2018Article
- Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation.Frontiers in endocrinology · 2018Review
- Extracellular microRNAs as messengers in the central and peripheral nervous system.Neuronal signaling · 2017Review
- MicroRNA Exocytosis by Vesicle Fusion in Neuroendocrine Cells.Frontiers in endocrinology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates gene expression inside the cell where they are transcribed, extracellular miRNA has been recently discovered outside the cells, proposing that miRNA might be released to participate in cell-to-cell communication. Despite its importance of extracellular miRNA, the molecular mechanisms by which miRNA can be stored in vesicles and released by vesicle fusion remain enigmatic. Using next-generation sequencing, vesicle purification techniques, and synthetic neurotransmission, we observe that large dense-core vesicles (LDCVs) contain a variety of miRNAs including miR-375. Furthermore, miRNA exocytosis is mediated by the SNARE complex and accelerated by Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.