SynthesisJournal of perinatology : official journal of the California Perinatal Association2017
Standardized feeding regimen for reducing necrotizing enterocolitis in preterm infants: an updated systematic review.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Nutritional management of neonates who undergo major surgery for gastrointestinal disorders: a joint position paper of the Italian Society of Neonatology (SIN), the Italian Society of Pediatric Surgery (SICP), and the Italian Society of Pediatric Nutrition (SINUPE).Italian journal of pediatrics · 2026Guideline
- Long-term neurodevelopment in preterm neonates with necrotizing enterocolitis: systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Influencing factors for surgical treatment in neonatal necrotizing enterocolitis: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Early erythropoietin for preventing necrotizing enterocolitis in preterm neonates - an updated meta-analysis.European journal of pediatrics · 2022Pooled it
- Clinical Outcomes Related to the Gastrointestinal Trophic Effects of Erythropoietin in Preterm Neonates: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- Early progressive feeding in extremely preterm infants: a randomized trial.The American journal of clinical nutrition · 2018Trial
- Necrotizing Enterocolitis in Preterm Infants: An Inflammatory Condition at the Crossroads of Intestinal Immaturity, Dysbiosis, and Nutrition.International journal of pediatrics · 2026Review
- Donor human milk pasteurization methods and the effect on milk components as they relate to Necrotizing enterocolitis.Seminars in fetal & neonatal medicine · 2025Review
- Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Impact of the Pre-Operative Standardized Nutritional Protocol in Infants with Congenital Heart Disease (CHD).Journal of cardiovascular development and disease · 2025Article
- Standardizing feeding strategies for preterm infants born greater than 1500 grams.Pediatric research · 2025Article
- Standardizing feeding strategies in preterm infants with birth weight >1500 g: current perspective.Pediatric research · 2025Article
- Quality Improvement Project to Improve Adherence to Best Practices to Decrease Incidence of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2025Article
- Analysis of NEC cases registered in the human milk bank database.Frontiers in pediatrics · 2025Article
- Maternal, neonatal, and nutritional risk factors for medical and surgical necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Nursing practice of routine gastric aspiration in preterm infants and its link to necrotizing enterocolitis: is the practice still clinically relevant?BMC nursing · 2024Article
- Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention.Paediatric drugs · 2024Review
- Multidisciplinary evidence-based tools for improving consistency of care and neonatal nutrition.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Role of practice standardization in outcome optimization for CDH.World journal of pediatric surgery · 2024Review
- Transfusion-associated necrotising enterocolitis in very low birth weight babies: transfusion and feeding practices in two neonatal units in Bloemfontein, Free State.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA systematic review (2005) of observational studies has reported 87% reduction in the incidence of necrotizing enterocolitis (NEC) after introducing standardized feeding regimen (SFR) in preterm infants. Considering the many new studies in this field since 2005 and the continued health burden of NEC, we aimed to systematically review the incidence of NEC in preterm infants 'before' vs 'after' implementing a SFR. STUDY
designPubMed, EMBASE, CINAHL and E-abstracts from the Pediatric Academic Society meetings and other pediatric and neonatal conference proceedings were searched in May 2016. Observational studies reporting incidence of NEC before and after implementing a SFR were included. Relevant data were extracted independently by two reviewers. Meta-analysis was conducted using random effects model (REM) and results rechecked with fixed effects model.
resultsPooled results from 15 observational studies (N=18 160) using REM showed that SFR significantly reduced the incidence of NEC (risk ratio 0.22; 95% confidence interval 0.13 to 0.36; P<0.00001; I
conclusionSFR continues to be an important tool in prevention of NEC in preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.