Evidence map›Paper›PMID 28358331›Full record

ArticleMolecules (Basel, Switzerland)2017

Absorption, Metabolic Stability, and Pharmacokinetics of Ginger Phytochemicals.

Rao Mukkavilli, Chunhua Yang, Reenu Singh Tanwar, Ahmed Ghareeb, Latika Luthra, Ritu Aneja

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Polyphenol-Rich Ginger (Molecules (Basel, Switzerland) · 2022
    Review
  13. Article
  14. Article
  15. Molecules (Basel, Switzerland) · 2022
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rao MukkavilliDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA. vmukkavilli@gsu.edu.
Chunhua YangDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA. ychnjcpu@gmail.com.
Reenu Singh TanwarDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA. drreenu10@gmail.com.
Ahmed GhareebDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA. afghareeb80@gmail.com.
Latika LuthraDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA. latika.luthra@yahoo.com.
Ritu AnejaDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA. raneja@gsu.edu.
Georgia State University · US

Funding

Evaluation of HSET as a Novel Theranostic Target for Breast Cancer TherapyR01CA169127 · NCI · GEORGIA STATE UNIVERSITY · PI ANEJA, RITU · 2012 to 2016
$1.7M
NCI NIH HHS R01 CA169127
6 · The paper itself

Abstract

We have previously demonstrated promising anticancer efficacy of orally-fed whole ginger extract (GE) in preclinical prostate models emphasizing the importance of preservation of the natural "milieu". Essentially, GE primarily includes active ginger phenolics viz., 6-gingerol (6G), 8-gingerol (8G), 10-gingerol (10G), and 6-shogaol (6S). However, the druglikeness properties of active GE phenolics like solubility, stability, and metabolic characteristics are poorly understood. Herein, we determined the physicochemical and biochemical properties of GE phenolics by conducting

Indexed as

Administration, OralAnimalsDogsHumansHydrogen-Ion ConcentrationKetoconazoleLiverMicePhenolsPhytochemicalsPlant ExtractsRatsSolubilityZingiber officinaleKetoconazolePhenolsPhytochemicalsPlant Extractsbiopharmaceutical drug disposition classification systemgingerliquid chromatography tandem mass spectrometrymicrosomal stabilitypharmacokineticssolubility

Identifiers

PMID28358331
PMCPMC6154694
OpenAlexW2604647761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.