Evidence map›Paper›PMID 28358273›Full record

ReviewAutophagy2017

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets.

Pooneh Mokarram, Mohammed Albokashy, Maryam Zarghooni, Mohammad Amin Moosavi, Zahra Sepehri, Qi Min Chen, Andrzej Hudecki, Aliyeh Sargazi, Javad Alizadeh, Adel Rezaei Moghadam and 6 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Autophagy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Pooled it
  2. Investigation ofMedicina (Kaunas, Lithuania) · 2019
    Pooled it
  3. Review
  4. Review
  5. Article
  6. Frontiers in immunology · 2026
    Article
  7. Review
  8. Article
  9. NRF2 as a ferroptosis gatekeeper in colorectal cancer: implications for therapy.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Regulation of autophagy by Rab27B in colorectal cancer.The international journal of biochemistry & cell biology · 2024
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Pooneh Mokarrama Colorectal Research Center and Department of Biochemistry , School of Medicine, Shiraz University of Medical Sciences , Shiraz , Iran.
Mohammed Albokashyb Department of Human Anatomy and Cell Science , Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba , Winnipeg , MB , Canada.
Maryam Zarghoonic Zabol University of Medical Sciences , Zabol , Iran.
Mohammad Amin Moosavie Department of Molecular Medicine , Institute of Medical Biotechnology, National Institute for Genetic Engineering and Biotechnology , Tehran , Iran.
Zahra Sepehric Zabol University of Medical Sciences , Zabol , Iran.
Qi Min Chenb Department of Human Anatomy and Cell Science , Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba , Winnipeg , MB , Canada.
Andrzej Hudeckif Institute of Nonferrous Metals , Gliwice , Poland.
Aliyeh Sargazic Zabol University of Medical Sciences , Zabol , Iran.
Javad Alizadehb Department of Human Anatomy and Cell Science , Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba , Winnipeg , MB , Canada.
Adel Rezaei Moghadamb Department of Human Anatomy and Cell Science , Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba , Winnipeg , MB , Canada.
Mohammad Hashemig Department of Clinical Biochemistry , School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran.
Hesam Movassaghh Department of Immunology , Rady Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg , MB , Canada.
Thomas Klonischb Department of Human Anatomy and Cell Science , Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba , Winnipeg , MB , Canada.
Ali Akbar Owjii Department of Clinical Biochemistry , School of Medicine, Shiraz Medical University , Shiraz , Iran.
Marek J Łosj Małopolska Centre of Biotechnology , Jagiellonian University , Krakow , Poland ; LinkoCare Life Sciences AB , Sweden.
Saeid Ghavamib Department of Human Anatomy and Cell Science , Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba , Winnipeg , MB , Canada.
University of Manitoba · CAShiraz University of Medical Sciences · IRZabol University of Medical Sciences · IRJagiellonian University · PLŁukasiewicz Research Network - Institute of Non-Ferrous Metals · PLNational Institute of Genetic Engineering and Biotechnology · IRUniversity of Toronto · CAZahedan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still remains a major life-threatening malignancy. CRC etiology entails both genetic and environmental factors. Macroautophagy/autophagy and the unfolded protein response (UPR) are fundamental mechanisms involved in the regulation of cellular responses to environmental and genetic stresses. Both pathways are interconnected and regulate cellular responses to apoptotic stimuli. In this review, we address the epidemiology and risk factors of CRC, including genetic mutations leading to the occurrence of the disease. Next, we discuss mutations of genes related to autophagy and the UPR in CRC. Then, we discuss how autophagy and the UPR are involved in the regulation of CRC and how they associate with obesity and inflammatory responses in CRC. Finally, we provide perspectives for the modulation of autophagy and the UPR as new therapeutic options for CRC treatment.

Indexed as

AnimalsApoptosisAutophagyColonic NeoplasmsColorectal NeoplasmsEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressHumansUnfolded Protein ResponseEndoplasmic Reticulum Chaperone BiPautophagyBeclin 1cancer therapycolorectal cancerER-stressGRP78unfolded protein response

Identifiers

PMID28358273
PMCPMC5446063
OpenAlexW2590621618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.