ArticleJournal of natural products2017
Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.
Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Soils and spoils: mineralogy and geochemistry of mining and processing wastes from lead and zinc mining at the Gratz Mine, Owen County, Kentucky.Journal of soils and sediments · 2022Article
- Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies.Journal of applied microbiology · 2022Review
- Structure and Function of a Dual Reductase-Dehydratase Enzyme System Involved inACS chemical biology · 2021Article
- Abyssomicins-A 20-Year Retrospective View.Marine drugs · 2021Review
- The crystal structure of AbsH3: A putative flavin adenine dinucleotide-dependent reductase in the abyssomicin biosynthesis pathway.Proteins · 2021Article
- Atypical Spirotetronate Polyketides Identified in the Underexplored GenusThe Journal of organic chemistry · 2020Article
- Article
- New peptidendrocins and anticancer chartreusin from an endophytic bacterium ofAnnals of translational medicine · 2020Article
- Diversity of PKS and NRPS gene clusters between Streptomyces abyssomicinicus sp. nov. and its taxonomic neighbor.The Journal of antibiotics · 2020Article
- Out of the Abyss: Genome and Metagenome Mining Reveals Unexpected Environmental Distribution of Abyssomicins.Frontiers in microbiology · 2020Article
- Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces.Journal of natural products · 2019Article
- Puromycins B-E, Naturally Occurring Amino-Nucleosides Produced by the Himalayan Isolate Streptomyces sp. PU-14G.Journal of natural products · 2018Article
- Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis.Molecules (Basel, Switzerland) · 2018Review
- Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802.Microbial cell factories · 2018Article
- Natural Product Discovery Using Planes of Principal Component Analysis in R (PoPCAR).Metabolites · 2017Article
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Authors and funding
14 authors.
Funding
Abstract
The structures of 12 new "enantiomeric"-like abyssomicin metabolites (abyssomicins M-X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
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