Evidence map›Paper›PMID 28358158›Full record

ArticleNanoscale2017

Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT.

R L Blackmon, S M Kreda, P R Sears, B S Chapman, D B Hill, J B Tracy, L E Ostrowski, A L Oldenburg

Open access · greenAbstract read
In one paragraph

Article in Nanoscale, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Journal of biomedical optics · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. TheThe European respiratory journal · 2018
    Article
  8. Diffusion tensor optical coherence tomography.Physics in medicine and biology · 2018
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

R L BlackmonDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, NC 27599-3255, USA. aold@physics.unc.edu.
S M Kreda
P R Sears
B S Chapman
D B Hill
J B Tracy
L E Ostrowski
A L Oldenburg
University of North Carolina at Chapel Hill · USNorth Carolina State University · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
The Role of Airway Surface Liquid Nucleotides/Nucleosides in Volume HomeostasisP01HL034322 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 1986 to 2011
$22.1M
INTERACTIVE GRAPHICS FOR MOLECULAR STUDIES &MICROSCOPYP41EB002025 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUPERFINE, RICHARD · 2003 to 2019
$16.9M
Synthesis of Effective and Safe Mucolytics for Pulmonary DiseaseUH2HL123645 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2014 to 2015
$2.9M
Anatomic optical coherence tomography for quantitative bronchoscopyR01HL123557 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L, ZDANSKI, CARLTON J · 2015 to 2017
$1.9M
Imaging nanophysical properties of actively transporting bronchial mucusR21HL130901 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L · 2016 to 2017
$418k
Development of a method for in situ nanorheology of human airway mucusR21HL111968 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L · 2012 to 2013
$392k
NHLBI NIH HHS P01 HL034322NHLBI NIH HHS R01 HL123557NHLBI NIH HHS R21 HL111968NHLBI NIH HHS R21 HL130901NHLBI NIH HHS UH2 HL123645NIBIB NIH HHS P41 EB002025NIDDK NIH HHS P30 DK065988NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

The solid concentration of pulmonary mucus (wt%) is critical to respiratory health. In patients with respiratory disease, such as Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disorder (COPD), mucus hydration is impaired, resulting in high wt%. Mucus with high wt% is a hallmark of pulmonary disease that leads to obstructed airways, inflammation, and infection. Methods to measure mucus hydration in situ and in real-time are needed for drug development and personalized therapy. We employed plasmonic gold nanorod (GNR) biosensors that intermittently collide with macromolecules comprising the mucus mesh as they self-diffuse, such that GNR translational diffusion (D

Indexed as

Biosensing TechniquesGoldNanotubesBronchiCells, CulturedDiffusionEpithelial CellsHumansLung DiseasesMucusTomography, Optical CoherenceGold

Identifiers

PMID28358158
PMCPMC5473168
OpenAlexW2602714375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.