ArticleScientific reports2017
Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
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- Bioactive Phytoconstituents and Their Therapeutic Potentials in the Treatment of Haematological Cancers: A Review.Life (Basel, Switzerland) · 2023Review
- Synthesis and Biological Evaluation of Novel Fusidic Acid Derivatives as Two-in-One Agent with Potent Antibacterial and Anti-Inflammatory Activity.Antibiotics (Basel, Switzerland) · 2022Article
- Alpha-glucosidase inhibitors fromSaudi journal of biological sciences · 2022Article
- Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors.Frontiers in chemistry · 2022Article
- Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases.International journal of molecular sciences · 2021Review
- Novel SynthesizedInternational journal of molecular sciences · 2021Article
- 3-Pyridinylidene Derivatives of Chemically Modified Lupane and Ursane Triterpenes as Promising Anticancer Agents by Targeting Apoptosis.International journal of molecular sciences · 2021Article
- Rational Design of Novel Inhibitors of α-Glucosidase: An Application of Quantitative Structure Activity Relationship and Structure-Based Virtual Screening.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Biotransformation of Oleanane and Ursane Triterpenic Acids.Molecules (Basel, Switzerland) · 2020Review
- Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid.Biomolecules · 2020Review
- Ursolic Acid and Its Derivatives as Bioactive Agents.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ursolic acid (UA) is a major pentacyclic triterpenoid in plants, vegetables and fruits, which has been reported to have a potential anti-diabetic activity. Despite various semi-synthetic ursolic acid derivatives already described, new derivatives still need to be designed and synthesized to further improve the anti-diabetic activity. In the present study, two series of novel UA derivatives, were synthesized and their structures were confirmed. The enzyme inhibition activities of semi-synthesized analogues against α-glucosidase were screened in vitro. The results indicated that most of UA derivatives showed a significant inhibitory activity, especially analogues UA-O-i with the IC
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