Evidence map›Paper›PMID 28357965›Full record

ArticleEpidemiology and infection2017

Racial differences in seroprevalence of HAV and HEV in blood donors in the Western Cape, South Africa: a clue to the predominant HEV genotype?

T Lopes, R Cable, C Pistorius, T Maponga, S Ijaz, W Preiser, R Tedder, M I Andersson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Transfusion-transmitted hepatitis E: What we know so far?World journal of gastroenterology · 2022
    Review
  10. Epidemiology of Genotype 1 and 2 Hepatitis E Virus Infections.Cold Spring Harbor perspectives in medicine · 2019
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

T LopesDivision of Medical Virology,Department of Pathology,University of Stellenbosch,South Africa.
R CableWestern Province Blood Transfusion Service,Cape Town,South Africa.
C PistoriusWestern Province Blood Transfusion Service,Cape Town,South Africa.
T MapongaDivision of Medical Virology,Department of Pathology,University of Stellenbosch,South Africa.
S IjazVirus Reference Department,Public Health England,London,UK.
W PreiserDivision of Medical Virology,Department of Pathology,University of Stellenbosch,South Africa.
R TedderVirus Reference Department,Public Health England,London,UK.
M I AnderssonDivision of Medical Virology,Department of Pathology,University of Stellenbosch,South Africa.
Stellenbosch University · ZAPublic Health England · GBSouth African National Blood Service · ZAUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. This infection causes major water-borne outbreaks in low- and middle-income countries, whilst in industrialised countries this infection is zoonotic. These differences in epidemiology are related to different HEV genotypes. HEV genotype 3 is a zoonotic infection, whilst genotype 2 causes large outbreaks. This study determined the seroprevalence of HEV in blood donors from the Western Cape. Anti-hepatitis A virus (anti-HAV) antibody was detected in 184/300 (61%) donors. Antibody to HEV (anti-HEV) was detected in 78 of 300 donors (26%). It was highest in mixed race donors (62/100), followed by white donors (23/100) and lowest in black donors (19/100) P = 0.019. Since it is thought that genotypes 1 and 2 predominate both viruses would be acquired by the oro-faecal route, it is surprising that HEV seroprevalence does not mirror that of HAV. We postulate that this may reflect differences in socio-economic status and consumption of dietary meat. So the marked divergence between HEV and HAV seroprevalence may be the result of different routes of transmission. Further data are needed to explore the risk factors associated with HEV infection.

Indexed as

Blood DonorsGenotypeAdolescentAdultAgedFemaleHepatitis AHepatitis AntibodiesHepatitis A virusHepatitis EHepatitis E virusHumansMaleMiddle AgedPrevalenceSeroepidemiologic StudiesHepatitis AntibodiesEpidemiologyhepatitis Eliver infectionviral hepatitis

Identifiers

PMID28357965
PMCPMC9203323
OpenAlexW2603342864

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.