Evidence map›Paper›PMID 28357808›Full record

ArticleMolecular neurobiology2018

PKMζ Is Not Required for Development of Postsurgical Pain.

Sufang Liu, Changsheng Li, Yan Guo, Ying Xing, Feng Tao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sufang LiuDepartment of Physiology and Neurobiology, Zhengzhou University School of Medicine, Zhengzhou, Henan, China.
Changsheng LiThe Affiliated Anti-Cancer Hospital at Zhengzhou University, Zhengzhou, Henan, China.
Yan GuoThe First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Ying XingDepartment of Physiology and Neurobiology, Zhengzhou University School of Medicine, Zhengzhou, Henan, China.
Feng TaoDepartment of Physiology and Neurobiology, Zhengzhou University School of Medicine, Zhengzhou, Henan, China. tao@tamhsc.edu.
Zhengzhou University · CNGaston College · USShanxi Medical University · CN

Funding

Gender differences in stress-induced pain transition after surgeryR01DE022880 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI TAO, FENG · 2012 to 2016
$2.0M
A new animal model for stress-induced transition from acute to chronic painK02DE023551 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI TAO, FENG · 2014 to 2018
$564k
National Natural Science Foundation of China 81500962NIDCR NIH HHS K02 DE023551NIDCR NIH HHS R01 DE022880NIDCR NIH HHS R01 DE022880 and K02 DE023551
6 · The paper itself

Abstract

Previous studies have shown that protein kinase M zeta (PKMζ), a brain-specific isoform of protein kinase C, is involved in the central processing of nociception in several pain models by using a synthetic zeta inhibitory peptide. In the present study, we investigated whether PKMζ contributes to the pathogenesis of postsurgical pain using both conditional and conventional PKMζ knockout mice. Our results showed that the expression of PKMζ in anterior cingulate cortex, but not spinal cord, of the conditional PKMζ knockout mice was inhibited following tamoxifen injection. And the conditional PKMζ knockout mice displayed similar plantar incision-produced postsurgical pain responses as those in wild-type mice. Moreover, the expression of PKMζ was inhibited in both anterior cingulate cortex and spinal cord of the conventional PKMζ knockout mice. And there were no significant differences in the development of postsurgical pain among wild-type, heterozygous, and homozygous conventional PKMζ knockout mice. These data suggest that PKMζ is not required for the development of postsurgical pain after plantar incision.

Indexed as

AnimalsEstrogen AntagonistsHot TemperatureMiceMice, Inbred C57BLMice, KnockoutPain MeasurementPhysical StimulationPostoperative PainProtein Kinase CProtein Kinase C zetaTamoxifenEstrogen AntagonistsProtein Kinase CProtein Kinase C zetaTamoxifenAnterior cingulate cortexPKMζPlantar incisionPostsurgical painSpinal cordSynaptic plasticity

Identifiers

PMID28357808
PMCPMC5620111
OpenAlexW2599828909

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.