Evidence map›Paper›PMID 28357807›Full record

ArticleMolecular neurobiology2018

Dual MicroRNA to Cellular Prion Protein Inhibits Propagation of Pathogenic Prion Protein in Cultured Cells.

Sang-Gyun Kang, Chiye Kim, Judd Aiken, Han Sang Yoo, Debbie McKenzie

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sang-Gyun KangCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, Canada.
Chiye KimCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, Canada.
Judd AikenCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, Canada.
Han Sang YooDepartment of Infectious Diseases, College of Veterinary Medicine, BK21 PLUS, Seoul National University, Seoul, 08826, Republic of Korea. yoohs@snu.ac.kr.
Debbie McKenzieCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, Canada. debbie.mckenzie@ualberta.ca.
University of Alberta · CASeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prion diseases are fatal transmissible neurodegenerative disorders affecting humans and various mammals. In spite of intensive efforts, there is no effective cure or treatment for prion diseases. Cellular forms of prion protein (PrP

Indexed as

AnimalsCell Line, TumorCells, CulturedCell SurvivalHEK293 CellsHumansLipopolysaccharidesMiceMicroRNAsPrion ProteinsLipopolysaccharidesMicroRNAsPrion ProteinsDifferentiated C2C12 cellsImmune stimulatorNeuronal and glial cellsPrion diseaseTherapeutic RNAi

Identifiers

PMID28357807
OpenAlexW2601547781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.