Evidence map›Paper›PMID 28357695›Full record

ArticleDigestive diseases and sciences2017

Impaired Interoception in a Preclinical Model of Functional Dyspepsia.

John H Winston, Jose E Aguirre, Xuan-Zheng Shi, Sushil K Sarna

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Choosing an Animal Model for the Study of Functional Dyspepsia.Canadian journal of gastroenterology & hepatology · 2018
    Review
  3. Gut Inflammation: More Than a Peripheral Annoyance.Digestive diseases and sciences · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

John H WinstonEnteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, McCullough Building, 301 University Blvd. 0764, Galveston, TX, 77555-1083, USA. jhwinsto@UTMB.EDU.
Jose E AguirreEnteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, McCullough Building, 301 University Blvd. 0764, Galveston, TX, 77555-1083, USA.
Xuan-Zheng ShiEnteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, McCullough Building, 301 University Blvd. 0764, Galveston, TX, 77555-1083, USA.
Sushil K SarnaEnteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, McCullough Building, 301 University Blvd. 0764, Galveston, TX, 77555-1083, USA.ORCID 0000-0002-4199-8837
The University of Texas Medical Branch at Galveston · US

Funding

Molecular Mechanisms of Environmental InjuryT32ES007254 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 1990 to 2022
$6.6M
CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASER01DK032346 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SARNA, SUSHIL K · 1986 to 2012
$4.0M
Developmental Origins of Functional DyspepsiaR01DK088796 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SARNA, SUSHIL K · 2011 to 2014
$1.4M
Naitional institute of Digestive Diabetes and Kidney Diseasess 5R01DK088796NIDDK NIH HHS R01 DK032346NIDDK NIH HHS R01 DK088796NIEHS NIH HHS T32 ES007254
6 · The paper itself

Abstract

introductionThe etiologies of functional dyspepsia symptoms, including postprandial distress syndrome, remain unknown. We tested the hypothesis that neonatal colon inflammation induces postprandial distress syndrome-like symptoms in adult life that associate with increased activation of vagal afferent pathways and forebrain limbic regions.

resultsThese rats showed a significant decrease in nutrient meal consumption to satiety after an overnight fast, decrease in gastric emptying, decrease in total distance traveled, and decrease in percent distance traveled in midfield versus control rats in open field test, indicating postprandial anxiety- and depression-like behaviors. Adult naïve rats treated with oral iodoacetamide to induce H. pylori-like mild gastritis demonstrated similar postprandial effects as the above rats.

conclusionsWe concluded that neonatal colon inflammation is a risk factor for the development of postprandial distress syndrome-like symptoms. While mild gastritis can induce symptoms similar to those of neonatal colon inflammation, gastritis in these rats does not worsen the symptoms.

Indexed as

Disease Models, AnimalAnimalsBrainDyspepsiaGastritisInflammation MediatorsInteroceptionMalePostprandial PeriodRandom AllocationRatsRats, Sprague-DawleyInflammation MediatorsAnxietyFunctional dyspepsiaGastric emptyingVisceral hypersensitivityVisceral pain

Identifiers

PMID28357695
PMCPMC5559576
OpenAlexW2601293757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.