Evidence map›Paper›PMID 28357680›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2017

Visual function quality of life measure changes upon conversion to neovascular age-related macular degeneration in second eyes.

Yannis M Paulus, Joan L Jefferys, Barbara S Hawkins, Adrienne W Scott

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Yannis M PaulusWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0615-628X
Joan L JefferysWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Barbara S HawkinsWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Adrienne W ScottWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA. ascott28@jhmi.edu.

Funding

Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
NEI NIH HHS K12 EY022299
6 · The paper itself

Abstract

purposeTo determine changes in quality of life measures when choroidal neovascularization (CNV) developed in the second eye of patients with initially unilateral neovascular age-related macular degeneration (AMD).

methodsWe analyzed responses to the 39-item National Eye Institute Visual Function Questionnaire (NEI-VFQ), 36-item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS) at baseline, and prior to and following second eye CNV diagnosis in 92 participants enrolled in two Submacular Surgery Trials. Paired t-tests for sample sizes over 30 and Wilcoxon signed-rank tests for sample sizes <30 were performed to compare scores.

resultsCNV development resulted in statistically and clinically significant changes in responses to 20 of 39 NEI-VFQ items, indicating visual function decline during a mean interval of 25 months. Little difference was noted between baseline scores and prior to CNV diagnosis, which averaged 8.9 months duration. Subscales demonstrated a statistically significant decline in general vision, near activities, distance activities, social functioning, role difficulties, dependency, and driving. There were minimal changes in the HADS and SF-36 scales.

conclusionCNV development in the second eye had a dramatic effect on visual functioning based on patient responses to the NEI-VFQ questionnaire. Our investigation is believed to be the first study using data collected prospectively to demonstrate vision-related quality of life changes that resulted from development of CNV in AMD patients.

Indexed as

AgedFemaleHumansMacular DegenerationMaleQuality of LifeVisual AcuityAge-related macular degenerationChoroidal neovascularizationNational Eye Institute Visual Function QuestionnaireQuality of LifeSecond eyesSubmacular Surgery Trials

Identifiers

PMID28357680
PMCPMC5511091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.