Evidence map›Paper›PMID 28357636›Full record

ReviewNeurocritical care2018

Probable Catastrophic Antiphospholipid Syndrome with Intracerebral Hemorrhage Secondary to Epstein-Barr Viral Infection.

Mark P Plummer, Adam M H Young, Ronan O'Leary, Maxwell S Damian, Andrea Lavinio

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Neurocritical care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. COVID-19, Antiphospholipid Antibodies, and Catastrophic Antiphospholipid Syndrome: A Possible Association?Clinical medicine insights. Arthritis and musculoskeletal disorders · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mark P PlummerNeurosciences and Trauma Critical Care Unit, Addenbrooke's Hospital, Cambridge, University Hospitals, Cambridge, CB2 0QQ, UK. mark.philip.plummer@gmail.com.
Adam M H YoungNeurosciences and Trauma Critical Care Unit, Addenbrooke's Hospital, Cambridge, University Hospitals, Cambridge, CB2 0QQ, UK.
Ronan O'LearyNeurosciences and Trauma Critical Care Unit, Addenbrooke's Hospital, Cambridge, University Hospitals, Cambridge, CB2 0QQ, UK.
Maxwell S DamianNeurosciences and Trauma Critical Care Unit, Addenbrooke's Hospital, Cambridge, University Hospitals, Cambridge, CB2 0QQ, UK.
Andrea LavinioNeurosciences and Trauma Critical Care Unit, Addenbrooke's Hospital, Cambridge, University Hospitals, Cambridge, CB2 0QQ, UK.
Addenbrooke's Hospital · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCatastrophic antiphospholipid syndrome (CAPS) is a rare, severe variant of antiphospholipid syndrome with a high mortality rate. We report a unique case of CAPS secondary to Epstein-Barr viral (EBV) infection complicated by pulmonary and intracerebral hemorrhage. A review of the CAPS literature relevant to intensive care practice is used to outline a rational approach to diagnosis and management.

methodsAll data are from a single patient admitted to the Neurosciences Critical Care Unit in Addenbrooke's Hospital, Cambridge, in March 2016. Medline, Web of Science, PubMed, and the Cochrane Library were searched through September 2016 without restrictions for cases of CAPS, management of CAPS in the intensive care unit, and hemorrhage complicating CAPS. The patient gave express written consent to access and publish these data.

resultsThis is only the second reported case of probable CAPS secondary to EBV infection. Furthermore, pulmonary and intracerebral hemorrhage is rare manifestations of this multisystem prothrombotic state which provided unique challenges to the management.

conclusionsWhile rare, CAPS should be considered in any patient presenting with rapidly progressive multiorgan failure, evidence of thrombotic microangiopathy, and antiphospholipid antibodies. A high index of suspicion is required as early, aggressive, multimodal treatment with anticoagulation, and immunosuppression improves outcomes.

Indexed as

AdultAntiphospholipid SyndromeCerebral HemorrhageEpstein-Barr Virus InfectionsHumansMaleYoung AdultCAPSCatastrophic antiphospholipid syndromeCerebral hemorrhageIntensive carePulmonary hemorrhage

Identifiers

PMID28357636
OpenAlexW2599754396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.