SynthesisJournal of bone and mineral metabolism2018
The relationship between subclinical thyroid dysfunction and the risk of fracture or low bone mineral density: a systematic review and meta-analysis of cohort studies.
Synthesis in Journal of bone and mineral metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis.BMJ open · 2019Pooled it
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- Association between thyroid function and osteopenia or osteoporosis: a cross-sectional study in China.Scientific reports · 2025Article
- Factors associated with post-operative delirium in hip fracture patients: what should we care.European journal of medical research · 2022Article
- Study protocol to develop a core outcome set for thyroid dysfunction to bridge the unmet needs of patient-centred care.BMJ open · 2021Article
- Subclinical thyroid dysfunction, bone mineral density, and osteoporosis in a middle-aged Korean population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study.BMJ (Clinical research ed.) · 2019Article
- [Impact of thyroid diseases on bone].Der Internist · 2018Review
- Thyroid diseases and bone health.Journal of endocrinological investigation · 2018Review
- Relationship between Hypothyroidism and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.Frontiers in endocrinology · 2017Article
- Changes in Bone Mineral Density Following Levothyroxine Therapy in Hypothyroidism - A Prospective, Observational Study.AACE endocrinology and diabetesArticle
Corrections and comments
- Retraction · 2019-08-02Author Unresponsive · Euphemisms for Plagiarism · Objections by Author(s) · Plagiarism of/in Article ·
- Retracted
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to assess the risk of fractures or low bone mineral density (BMD) associated with subclinical thyroid dysfunction among cohorts. We systematically searched Medline (via PubMed), EMBASE, Cochrane Library, Web of Science, CENTRAL and SinoMed up to 31 July 2016 to identify cohort studies which have analyzed associations between subclinical thyroid dysfunction and fracture or BMD. A total of 19 population-based cohorts including 79,368 participants with relationships between subclinical thyroid dysfunction and fractures or BMD were identified as eligible for this meta-analysis. Subclinical hypothyroidism was associated with relative risks (RRs) of 1.34 (95% confidence interval [CI] 1.14, 1.58; I
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.