Evidence map›Paper›PMID 28357562›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2018

In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders.

Daniel F Hermens, Sean N Hatton, Rico S C Lee, Sharon L Naismith, Shantel L Duffy, G Paul Amminger, Manreena Kaur, Elizabeth M Scott, Jim Lagopoulos, Ian B Hickie

Abstract read
PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 8 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 8 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  16. Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Daniel F HermensBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia. daniel.hermens@sydney.edu.au.
Sean N HattonBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Rico S C LeeBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Sharon L NaismithBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Shantel L DuffyBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
G Paul AmmingerOrygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Manreena KaurBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Elizabeth M ScottBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Jim LagopoulosBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
Ian B HickieBrain and Mind Centre, The University of Sydney, 100 Mallett Street, Camperdown, NSW, 2050, Australia.
University of Sydney · AUMonash University · AUOrygen Youth Health · AUUniversity of California, San Diego · US

Funding

National Health and Medical Research Council 1061043
6 · The paper itself

Abstract

Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying mechanisms remain unclear, disruption to normal myelination due to oxidative stress is thought to play a key role. We aimed to determine whether fronto-limbic WM integrity is compromised, and associated with in vivo antioxidant levels (indexed by glutathione; GSH), in young adults with unipolar depression (DEP) and bipolar (BD) disorders. Ninety-four patients with DEP, 76 with BD and 59 healthy controls (18-30 years) underwent diffusion tensor and proton magnetic resonance spectroscopy imaging. Fractional anisotropy (FA) was calculated from the cingulum bundle (cingulate, hippocampus), fornix, stria terminalis (ST) and uncinate fasciculus tracts. GSH concentration was measured in anterior cingulate cortex (ACC) and hippocampus (HIPP). Compared to controls, DEP showed significantly reduced FA in ST, whereas BD did not significantly differ in FA across the five tracts. There were significant positive correlations between ST-FA and HIPP-GSH across groups. Regression analysis revealed that having DEP or BD and reduced HIPP-GSH were significantly associated with reduced ST-FA. Similarly, decreased ST-FA was associated with poorer neuropsychological performance in conjunction with having DEP. Our findings suggest a structural disconnectivity specific to the limbic region of young adults with DEP. Decreased WM integrity was associated with depleted levels of hippocampal GSH suggesting that this particular disruption may be linked to oxidative stress at early stages of illness. Young adults with BD do not have the same degree of impairment.

Indexed as

Magnetic Resonance ImagingAdolescentAdultAnalysis of VarianceExecutive FunctionFemaleFrontal LobeHumansImage Processing, Computer-AssistedLearningLimbic SystemMagnetic Resonance SpectroscopyMaleMood DisordersNeural PathwaysNeuropsychological TestsBipolar disorderDepressionDiffusion tensor imagingGlutathioneHippocampusMagnetic resonance spectroscopy

Identifiers

PMID28357562
OpenAlexW2598027445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.