ArticleLab on a chip2017
Recognition-mediated particle detection under microfluidic flow with waveguide-coupled 2D photonic crystals: towards integrated photonic virus detectors.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Demonstration of Directly Nanoimprinted Silica-Titania Large-Size Vertical Grating Couplers for Multichannel Photonic Sensor Development.Materials (Basel, Switzerland) · 2025Article
- Roadmap on optical sensors.Journal of optics (2010) · 2024Review
- A Review on Photonic Sensing Technologies: Status and Outlook.Biosensors · 2023Review
- Biosensing with Silicon Nitride Microring Resonators Integrated with an On-Chip Filter Bank Spectrometer.ACS sensors · 2023Article
- 2D Material-Based Optical Biosensor: Status and Prospect.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Detection and Digital Resolution Counting of Nanoparticles with Optical Resonators and Applications in Biosensing.Chemosensors (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Label-free biodetection schemes compatible with standard CMOS fabrication methods constitute an important goal, as these are enabling tools for the mass production of high-sensitivity biosensors. Two-dimensional slab photonic crystal (2D slab-PhC) sensors have been posited as ultrahigh-sensitivity detection components, but to date recognition-mediated detection of viruses or simulants under flow has not been demonstrated. We report the design and optimization of a new W1 waveguide-coupled 2D slab-PhC sensor, with a geometry well suited to virus detection. Proof of concept experiments with fluorescent latex particles verified that the sensor could respond to infiltration of a single particle, both in air and under an aqueous cover layer. Subsequent experiments with antibody-functionalized sensors and virus simulants confirmed the ability of the device to detect virus-sized particles under flow via a recognition-mediated process. This work sets the stage for incorporation of 2D slab-PhC sensors into fully integrated photonic sensor systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.