Evidence map›Paper›PMID 28357420›Full record

ArticleChemical communications (Cambridge, England)2017

SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth.

Saumya Roy, Jun Y Axup, Jane S Forsyth, Rajib K Goswami, Benjamin M Hutchins, Krishna M Bajuri, Stephanie A Kazane, Vaughn V Smider, Brunhilde H Felding, Subhash C Sinha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Saporin fromToxins · 2020
    Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Saumya RoyDepartment of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. ssinha@rockefeller.edu.
Jun Y Axup
Jane S Forsyth
Rajib K Goswami
Benjamin M Hutchins
Krishna M Bajuri
Stephanie A Kazane
Vaughn V Smider
Brunhilde H Felding
Subhash C Sinha
Scripps Research Institute · US

Funding

Normalizing Breast Cancer Metabolism to Prevent Progression and Recurrence (PQ21)R01CA170737 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI FELDING, BRUNIE H. · 2012 to 2015
$2.1M
Vascular mechanisms regulating breast cancer brain metastasisR01CA170140 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELICEIRI, BRIAN P, FELDING, BRUNIE H. · 2012 to 2016
$1.8M
Selective Antibody ConjugatesR01CA120289 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI SINHA, SUBHASH C · 2007 to 2010
$1.1M
Antibody Fingerprinting of Triple Negative Breast Cancer by High Throughput FACSR21CA198595 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI FELDING, BRUNIE H., SMIDER, VAUGHN VASIL · 2015 to 2016
$457k
NCI NIH HHS R01 CA120289NCI NIH HHS R01 CA170140NCI NIH HHS R01 CA170737NCI NIH HHS R21 CA198595
6 · The paper itself

Abstract

Cell-targeting conjugates of Saporin 6, a ribosome inactivating protein (RIP), were prepared using the Saporin Ala 157 Cys mutant, a small molecule inhibitor (SMI) of integrins α

Identifiers

PMID28357420
PMCPMC6594371
OpenAlexW2596469211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.