Evidence map›Paper›PMID 28357373›Full record

ArticleMicrobial cell (Graz, Austria)2016

Erika Shor, Yina Wang, David S Perlin, Chaoyang Xue

Open access · goldAbstract readComment
In one paragraph

Article in Microbial cell (Graz, Austria), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The proteomic response ofmicroLife · 2025
    Article
  5. Article
  6. Review
  7. Macrophage Mediated Immunomodulation DuringFrontiers in cellular and infection microbiology · 2022
    Review
  8. Synergies with and Resistance to Membrane-Active Peptides.Antibiotics (Basel, Switzerland) · 2020
    Review
  9. Article
  10. Role of lipid transporters in fungal physiology and pathogenicity.Computational and structural biotechnology journal · 2019
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erika ShorPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Yina WangPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
David S PerlinPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA. ; Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Chaoyang XuePublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA. ; Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Rutgers, The State University of New Jersey · US

Funding

Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8M
Mechanism of GPCR Signaling-mediated Fungal Cell GigantismR21AI113368 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI XUE, CHAOYANG · 2014 to 2015
$449k
Regulation of ubiquitin-proteasome in Cryptococcus pathogenesisR21AI115204 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI XUE, CHAOYANG · 2015 to 2016
$437k
NIAID NIH HHS R01 AI109025NIAID NIH HHS R21 AI113368NIAID NIH HHS R21 AI115204
6 · The paper itself

Abstract

Human fungal infections are increasing in prevalence and acquisition of antifungal drug resistance, while our antifungal drug armamentarium remains very limited, constituting a significant public health problem. Despite the fact that prominent antifungal drugs target the fungal cell membrane, very little is known about how fungal membrane biology regulates drug-target interactions. Asymmetrical phospholipid distribution is an essential property of biological membranes, which is maintained by a group of transporters that dynamically translocate specific phospholipid groups across the membrane bilayer. Lipid flippase is the enzyme responsible for translocation of certain phospholipids, including phosphatidylserine (PS), across the plasma membrane from the exocytoplasmic to the cytoplasmic leaflet. Loss of lipid flippase leads to abnormal phospholipid distribution and impaired intracellular vesicular trafficking. The recent research article by Huang

Indexed as

antifungal drug resistanceCdc50Cryptococcus neoformanslipid flippasevirulence

Identifiers

PMID28357373
PMCPMC5349016
OpenAlexW2491560796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.