ReviewMicrobial cell (Graz, Austria)2016
Evidence for the hallmarks of human aging in replicatively aging yeast.
Review in Microbial cell (Graz, Austria), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 89 citations in OpenAlex.
- The limits of information in precise regulation of early multicellular life cycles.bioRxiv : the preprint server for biology · 2026Article
- Single-cell aging trajectories reveal a dynamic coupling between nuclear size and proteasome concentration.iScience · 2026Article
- Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespan.bioRxiv : the preprint server for biology · 2026Article
- Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models.Quantitative biology (Beijing, China) · 2025Article
- Tom70-mediated mitochondria-nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis.bioRxiv : the preprint server for biology · 2025Article
- Article
- Design principles of gene circuits for longevity.Trends in cell biology · 2025Review
- Unraveling Histone Loss in Aging and Senescence.Cells · 2024Review
- Senescence in yeast is associated with amplified linear fragments of chromosome XII rather than ribosomal DNA circle accumulation.PLoS biology · 2023Article
- Gametogenesis: Exploring an Endogenous Rejuvenation Program to Understand Cellular Aging and Quality Control.Annual review of genetics · 2022Review
- Article
- We are all aging, and here's why.Aging medicine (Milton (N.S.W)) · 2022Review
- DetecDiv, a generalist deep-learning platform for automated cell division tracking and survival analysis.eLife · 2022Article
- A complex systems approach to aging biology.Nature aging · 2022Review
- Review
- Single-cell image analysis to explore cell-to-cell heterogeneity in isogenic populations.Cell systems · 2021Review
- Protein interaction potential landscapes for yeast replicative aging.Scientific reports · 2021Article
- Replicative Aging in Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2020Review
- Article
- Poor old pores-The challenge of making and maintaining nuclear pore complexes in aging.The FEBS journal · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, efforts have been made to characterize the hallmarks that accompany and contribute to the phenomenon of aging, as most relevant for humans 1. Remarkably, studying the finite lifespan of the single cell eukaryote budding yeast (recently reviewed in 2 and 3) has been paramount for our understanding of aging. Here, we compile observations from literature over the past decades of research on replicatively aging yeast to highlight how the hallmarks of aging in humans are present in yeast. We find strong evidence for the majority of these, and summarize how yeast aging is especially characterized by the hallmarks of genomic instability, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, and mitochondrial dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.