ArticleMicrobial cell (Graz, Austria)2016
Bactericidal antibiotics induce programmed metabolic toxicity.
Article in Microbial cell (Graz, Austria), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- The role of bacterial metabolism in antimicrobial resistance.Nature reviews. Microbiology · 2025Review
- The tradeoffs between persistence and mutation rates at sub-inhibitory antibiotic concentrations inMicrobiology spectrum · 2025Article
- Tradeoff between lag time and growth rate drives the plasmid acquisition cost.Nature communications · 2023Article
- Microbial Metabolism Modulates Antibiotic Susceptibility within the Murine Gut Microbiome.Cell metabolism · 2019Article
- Microbial wars: Competition in ecological niches and within the microbiome.Microbial cell (Graz, Austria) · 2018Article
- Establishment of two Hypotheses for Gut Bacterial Alteration Process for Minimizing the Intestinal Communicable Diseases.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.