Evidence map›Paper›PMID 28357300›Full record

ArticleMicrobial cell (Graz, Austria)2015

Human Thyroid Cancer-1 (TC-1) is a vertebrate specific oncogenic protein that protects against copper and pro-apoptotic genes in yeast.

Natalie K Jones, Nagla T Arab, Rawan Eid, Nada Gharib, Sara Sheibani, Hojatollah Vali, Chamel Khoury, Alistair Murray, Eric Boucher, Craig A Mandato and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial cell (Graz, Austria), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Natalie K JonesDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada. ; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada. ; Present address: Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada.
Nagla T ArabDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada. ; Department of Biology, Queen's University, Kingston, Ontario, Canada.
Rawan EidDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada. ; Department of Biology, Queen's University, Kingston, Ontario, Canada.
Nada GharibDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada. ; Present address: Department of Biomedical Sciences, Queen's University, Kingston, Ontario, Canada.
Sara SheibaniDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada. ; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada. ; Present address: Defence Research and Development Canada, Alberta, Canada.
Hojatollah ValiDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Chamel KhouryDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada.
Alistair MurrayDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada. ; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Eric BoucherDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Craig A MandatoDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Paul G YoungDepartment of Biology, Queen's University, Kingston, Ontario, Canada.
Michael T GreenwoodDepartment of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario, Canada.
McGill University · CARoyal Military College of Canada · CADefence Research and Development Canada · CAQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human Thyroid Cancer-1 (hTC-1) protein, also known as C8orf4 was initially identified as a gene that was up-regulated in human thyroid cancer. Here we show that hTC-1 is a peptide that prevents the effects of over-expressing Bax in yeast. Analysis of the 106 residues of hTC-1 in available protein databases revealed direct orthologues in jawed-vertebrates, including mammals, frogs, fish and sharks. No TC-1 orthologue was detected in lower organisms, including yeast. Here we show that TC-1 is a general pro-survival peptide since it prevents the growth- and cell death-inducing effects of copper in yeast. Human TC-1 also prevented the deleterious effects that occur due to the over-expression of a number of key pro-apoptotic peptides, including

Indexed as

anti-apoptoticapoptosiscancercell deathcell survivalTC-1yeast

Identifiers

PMID28357300
PMCPMC5349172
OpenAlexW2103044736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.