ArticleMicrobial cell (Graz, Austria)2015
New roles for autophagy and spermidine in T cells.
Article in Microbial cell (Graz, Austria), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- In Vitro Antioxidant and Cellular Activities of Functionalized Spermidine by Conjugating with Ascorbic Acid in Human Skin Cells.Molecules (Basel, Switzerland) · 2026Article
- Polyamines in Ovarian Aging and Disease.International journal of molecular sciences · 2023Review
- Gut Microbial Metabolites on Host Immune Responses in Health and Disease.Immune network · 2023Review
- New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases.Aging and disease · 2021Review
- Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomycescerevisiae.Journal of cell science · 2021Article
- Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.Aging · 2020Observational
- Spermidine reduces cancer-related mortality in humans.Autophagy · 2019Article
- Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?Autophagy · 2019Article
- The crucial impact of lysosomes in aging and longevity.Ageing research reviews · 2016Review
- Spermidine protects mitochondria against amyloid-β oligomers.Journal of Alzheimer's disease reportsArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conserved lysosomal degradation pathway autophagy is now recognised as an essential cog in immune function. While functionally widespread in the innate immune system, knowledge of its roles in adaptive immunity is more limited. Although autophagy has been implicated in naïve T cell homeostasis, its requirement in antigen-specific T cells during infection was unknown. Using a murine model where the essential autophagy gene
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.