Evidence map›Paper›PMID 28357223›Full record

ArticleMicrobial cell (Graz, Austria)2014

Deletion of

Christopher Chin, Faith Donaghey, Katherine Helming, Morgan McCarthy, Stephen Rogers, Nicanor Austriaco

Open access · goldAbstract read
In one paragraph

Article in Microbial cell (Graz, Austria), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Sugar-induced cell death (SICD) inMicrobial cell (Graz, Austria) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Water extract fromHeliyon · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Filamentation protectsMicrobial cell (Graz, Austria) · 2016
    Article
  12. Micafungin induced apoptosis inMicrobial cell (Graz, Austria) · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christopher ChinDepartment of Biology, Providence College, Providence, RI 02918, U.S.A. ; Current address: University of Massachusetts School of Medicine, 55 Lake Ave. N., Worcester, MA 01655, U.S.A.
Faith DonagheyDepartment of Biology, Providence College, Providence, RI 02918, U.S.A.
Katherine HelmingDepartment of Biology, Providence College, Providence, RI 02918, U.S.A. ; Current address: Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, U.S.A.
Morgan McCarthyDepartment of Biology, Providence College, Providence, RI 02918, U.S.A.
Stephen RogersDepartment of Biology, Providence College, Providence, RI 02918, U.S.A.
Nicanor AustriacoDepartment of Biology, Providence College, Providence, RI 02918, U.S.A.
Providence College · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
Genetic Identification of Sulforaphane's Mechanism of Action in Yeast Cell DeathR15GM094712 · NIGMS · PROVIDENCE COLLEGE · PI AUSTRIACO, NICANOR · 2010 to 2010
$310k
NIGMS NIH HHS P20 GM103430NIGMS NIH HHS R15 GM094712
6 · The paper itself

Abstract

Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the enzyme, β(1,3)-D-glucan synthase. Loss of β(1,3)-D-glucan leads to osmotic instability and cell death. However, the precise mechanism of cell death associated with the cytotoxicity of caspofungin was unclear. We now provide evidence that

Indexed as

AIF1Candida albicanscaspofunginMCA1/YCA1programmed cell deathSaccharomyces cerevisiae

Identifiers

PMID28357223
PMCPMC5348969
OpenAlexW2134321030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.