Evidence map›Paper›PMID 28356872›Full record

ArticleJournal of medical biochemistry2016

The Relationship of Myocardial Collagen Metabolism and Reverse Remodeling after Cardiac Resynchronization Therapy.

Ivana Petrovic, Ivan Stankovic, Goran Milasinovic, Gabrijela Nikcevic, Bratislav Kircanski, Velibor Jovanovic, Srdjan Raspopovic, Nikola Radovanovic, Sinisa U Pavlovic

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Circulating biomarkers as predictors of left ventricular remodeling after myocardial infarction.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2021
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ivana PetrovicSchool of Medicine, University of Belgrade, Belgrade, Serbia.
Ivan StankovicDepartment of Cardiology, University Clinical Hospital Centre Zemun, Belgrade, Serbia.
Goran MilasinovicSchool of Medicine, University of Belgrade, Belgrade, Serbia; Pacemaker Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Gabrijela NikcevicPacemaker Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Bratislav KircanskiPacemaker Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Velibor JovanovicPacemaker Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Srdjan RaspopovicPacemaker Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Nikola RadovanovicPacemaker Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Sinisa U PavlovicSchool of Medicine, University of Belgrade, Belgrade, Serbia; Pacemaker Center, Clinical Center of Serbia, Medical Faculty, University of Belgrade, Belgrade, Serbia.
University of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the majority of patients with a wide QRS complex and heart failure resistant to optimal medical therapy, cardiac resynchronization therapy (CRT) leads to reverse ventricular remodeling and possibly to changes in cardiac collagen synthesis and degradation. We investigated the relationship of biomarkers of myocardial collagen metabolism and volumetric response to CRT.

methodsWe prospectively studied 46 heart failure patients (mean age 61±9 years, 87% male) who underwent CRT implantation. Plasma concentrations of amino-terminal propeptide type I (PINP), a marker of collagen synthesis, and carboxy-terminal collagen telopeptide (CITP), a marker of collagen degradation, were measured before and 6 months after CRT. Response to CRT was defined as 15% or greater reduction in left ventricular end-systolic volume at 6-month follow-up.

resultsBaseline PINP levels showed a negative correlation with both left ventricular end-diastolic volume (r=-0.51; p=0.032), and end-systolic diameter (r=-0.47; p=0.049). After 6 months of device implantation, 28 patients (61%) responded to CRT. No significant differences in the baseline levels of PINP and CITP between responders and nonresponders were observed (p>0.05 for both). During follow-up, responders demonstrated a significant increase in serum PINP level from 31.37±18.40 to 39.2±19.19 μg/L (p=0.049), whereas in non-responders serum PINP levels did not significantly change (from 28.12±21.55 to 34.47± 18.64 μg/L; p=0.125). There were no significant changes in CITP levels in both responders and non-responders (p>0.05).

conclusionsLeft ventricular reverse remodeling induced by CRT is associated with an increased collagen synthesis in the first 6 months of CRT implantation.

Indexed as

cardiac resynchronization therapycollagen metabolismreverse remodeling

Identifiers

PMID28356872
PMCPMC5346789
OpenAlexW2417529397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.