ArticleInternational journal of nanomedicine2017
Synthesis, characterization, and antimicrobial properties of novel double layer nanocomposite electrospun fibers for wound dressing applications.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 106 citations in OpenAlex.
- Green Synthesis of Silver Nanoparticles fromMolecules (Basel, Switzerland) · 2026Article
- Smart Nanofibers in Wound Healing: Exploring Novel Combinations and Applications.Current drug delivery · 2026Review
- Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review.Beilstein journal of nanotechnology · 2025Review
- Fabrication and characterization of polyvinyl alcohol-chitosan composite nanofibers for carboxylesterase immobilization to enhance the stability of the enzyme.Scientific reports · 2024Article
- Antifungal Activity of Chitosan/Poly(Ethylene Oxide) Blend Electrospun Polymeric Fiber Mat Doped with Metallic Silver Nanoparticles.Polymers · 2023Article
- Multi-material electrospinning: from methods to biomedical applications.Materials today. Bio · 2023Review
- Current status and progress in research on dressing management for diabetic foot ulcer.Frontiers in endocrinology · 2023Review
- Recent Advances in Silver Nanoparticles Containing Nanofibers for Chronic Wound Management.Polymers · 2022Review
- Advances in Electrospun Hybrid Nanofibers for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2022Review
- Article
- Polysaccharide Electrospun Nanofibers for Wound Healing Applications.International journal of nanomedicine · 2022Review
- Biotechnological Applications of Polymeric Nanofiber Platforms Loaded with Diverse Bioactive Materials.Polymers · 2021Review
- New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation.Polymers · 2021Article
- Antimicrobial Double-Layer Wound Dressing Based on Chitosan/Polyvinyl Alcohol/Copper: In vitro and in vivo Assessment.International journal of nanomedicine · 2021Article
- Synthesis of FeHeliyon · 2020Article
- Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails.Antibiotics (Basel, Switzerland) · 2020Review
- Physical-Chemical Crosslinked ElectrospunInternational journal of nanomedicine · 2020Article
- Anthocyanin Colorimetric Strip for Volatile Amine Determination.International journal of food science · 2020Article
- A novel bilayer zein/MMT nanocomposite incorporated with H. perforatum oil for wound healing.Journal of materials science. Materials in medicine · 2019Article
- Fabrication of Electrospun Polymer Nanofibers with Diverse Morphologies.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, novel hybrid nanomaterials were developed for wound dressing applications with antimicrobial properties. Electrospinning was used to fabricate a double layer nanocomposite nanofibrous mat consisting of an upper layer of poly(vinyl alcohol) and chitosan loaded with silver nanoparticles (AgNPs) and a lower layer of polyethylene oxide (PEO) or polyvinylpyrrolidone (PVP) nanofibers loaded with chlorhexidine (as an antiseptic). The top layer containing AgNPs, whose purpose was to protect the wound site against environmental germ invasion, was prepared by reducing silver nitrate to its nanoparticulate form through interaction with chitosan. The lower layer, which would be in direct contact with the injured site, contained the antibiotic drug needed to avoid wound infections which would otherwise interfere with the healing process. Initially, the upper layer was electrospun, followed sequentially by electrospinning the second layer, creating a bilayer nanofibrous mat. The morphology of the nanofibrous mats was studied by scanning electron microscopy and transmission electron microscopy, showing successful nanofiber production. X-ray diffraction confirmed the reduction of silver nitrate to AgNPs. Fourier transform infrared spectroscopy showed a successful incorporation of the material used in the produced nanofibrous mats. Thermal studies carried out by thermogravimetric analysis indicated that the PVP-drug-loaded layer had the highest thermal stability in comparison to other fabricated nanofibrous mats. Antimicrobial activities of the as-synthesized nanofibrous mats against
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.