Evidence map›Paper›PMID 28356713›Full record

ArticleDrug design, development and therapy2017

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells.

Imaobong Christopher Etti, Abdullah Rasedee, Najihah Mohd Hashim, Ahmad Bustamam Abdul, Arifah Kadir, Swee Keong Yeap, Peter Waziri, Ibrahim Malami, Kian Lam Lim, Christopher J Etti

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Imaobong Christopher EttiPharmacology and Toxicology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia; Department of Pharmacology and Toxicology, University of Uyo, Uyo, Nigeria.
Abdullah RasedeeDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia.
Najihah Mohd HashimDepartment of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Ahmad Bustamam AbdulMAKNA-Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
Arifah KadirDepartment of Veterinary Preclinical Science, Universiti Putra Malaysia, Serdang, Malaysia.
Swee Keong YeapLaboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
Peter WaziriMAKNA-Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
Ibrahim MalamiMAKNA-Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
Kian Lam LimFaculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Cheras, Selangor, Malaysia.
Christopher J EttiDepartment of Agricultural and Food Engineering, University of Uyo, Uyo, Nigeria.
Universiti Putra Malaysia · MYUniversity of Uyo · NGUniversiti Tunku Abdul Rahman · MYUniversity of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artonin E is a prenylated flavonoid compound isolated from the stem bark of

Indexed as

Antineoplastic AgentsApoptosisCell Cycle CheckpointsCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorFlavonoidsG1 Phase Cell Cycle CheckpointsHumansMCF-7 CellsMitochondriaMolecular StructureReactive Oxygen SpeciesStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic Agentsartonin EFlavonoidsReactive Oxygen SpeciesTumor Suppressor Protein p53apoptosisArtonin Ebreast cancercell cyclelivin

Identifiers

PMID28356713
PMCPMC5367776
OpenAlexW2600100896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.