Evidence map›Paper›PMID 28356706›Full record

ArticleMolecular vision2017

A mutagenesis-derived

Jeremy R Charette, Sarah E Earp, Brent A Bell, Cheryl L Ackert-Bicknell, Dana A Godfrey, Sujata Rao, Bela Anand-Apte, Patsy M Nishina, Neal S Peachey

Open access · greenAbstract read
In one paragraph

Article in Molecular vision, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. JBMR plus · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Forward genetic analysis using OCT screening identifiesProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Review
  8. Reduced expression of theMolecular vision · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jeremy R CharetteThe Jackson Laboratory, Bar Harbor, ME.
Sarah E EarpCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Cole Eye Institute, Cleveland Clinic, Cleveland, OH.
Brent A BellCole Eye Institute, Cleveland Clinic, Cleveland, OH.
Cheryl L Ackert-BicknellThe Jackson Laboratory, Bar Harbor, ME; Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, NY.
Dana A GodfreyCenter for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, NY.
Sujata RaoCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Cole Eye Institute, Cleveland Clinic, Cleveland, OH.
Bela Anand-ApteCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Cole Eye Institute, Cleveland Clinic, Cleveland, OH.
Patsy M NishinaThe Jackson Laboratory, Bar Harbor, ME.
Neal S PeacheyCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Cole Eye Institute, Cleveland Clinic, Cleveland, OH; Louis Stokes Cleveland VA Medical Center, Cleveland, OH.
Jackson Laboratory · USCleveland Clinic · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
RETINAL DISEASE: MOLECULAR BASIS AND PATHOPHYSIOLOGYR01EY011996 · NEI · JACKSON LABORATORY · PI Patsy M Nishina · 1998 to 2026
$12.4M
Mouse Models for Vision ResearchR01EY016501 · NEI · JACKSON LABORATORY · PI NISHINA, PATSY M · 2005 to 2014
$9.4M
Regulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4M
Role of Retinoic Acid in the Regulation of the Blood-Retinal Barrier.R01EY026181 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2016 to 2020
$2.1M
Role of TIMP-3 in Ocular NeovascularizationR01EY016490 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2005 to 2009
$1.7M
Role of betacellulin in diabetic macular edemaR01EY020861 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2011 to 2014
$1.5M
BLRD VA IK6 BX005233NCI NIH HHS P30 CA034196NEI NIH HHS R01 EY011996NEI NIH HHS R01 EY016490NEI NIH HHS R01 EY016501NEI NIH HHS R01 EY020861NEI NIH HHS R01 EY026181NEI NIH HHS R01 EY027077
6 · The paper itself

Abstract

purposeFamilial exudative vitreoretinopathy (FEVR) is caused by mutations in the genes encoding low-density lipoprotein receptor-related protein (LRP5) or its interacting partners, namely frizzled class receptor 4 (FZD4) and norrin cystine knot growth factor (NDP). Mouse models for

methodsERGs were used to examine outer retinal physiology. The retinal vasculature was examined by

resultsThe

conclusionsThe phenotype of the

Indexed as

Bone DensityAnimalsElectroretinographyGene Expression RegulationHomozygoteLow Density Lipoprotein Receptor-Related Protein-5MaleMice, Inbred C57BLMutagenesisMutationOrgan SizePhenotypeRetinal VesselsWnt Signaling PathwayLow Density Lipoprotein Receptor-Related Protein-5

Identifiers

PMID28356706
PMCPMC5360454
OpenAlexW2601969688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.