Evidence map›Paper›PMID 28356514›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.

Jing Chen, Yong Zhang, Michael N Petrus, Wenming Xiao, Alina Nicolae, Mark Raffeld, Stefania Pittaluga, Richard N Bamford, Masao Nakagawa, Sunny Tianyi Ouyang and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 83 citations in OpenAlex.

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  19. Case Report: Identification of a novelFrontiers in oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Jing ChenLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Yong ZhangLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Michael N PetrusLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Wenming XiaoDivision of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079.
Alina NicolaeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Mark RaffeldLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Stefania PittalugaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Richard N BamfordTransponics, Jacobus, PA 17407.
Masao NakagawaLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Sunny Tianyi OuyangLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Alan L EpsteinPathology Department, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033.
Marshall E KadinDepartment of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908.
Annarose Del MistroVeneto Institute of Oncology, National Institute for Research and Treatment, 35128 Padua, Italy.
Richard WoessnerInnovative Medicines and Early Development Oncology, AstraZeneca Pharmaceuticals, Waltham, MA 02139.
Elaine S JaffeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Thomas A WaldmannLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892; tawald@helix.nih.gov.
Center for Cancer Research · USNational Cancer Institute · USAstraZeneca (United States) · USIstituto Oncologico Veneto · ITNational Center for Toxicological Research · USProvidence College · USUniversity of Southern California · US

Funding

Molecular Diagnostics Core LaboratoryZICBC011079 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI XI, LIQIANG · 2009 to 2025
$33.8M
Hematopathology DiagnosisZIABC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$14.5M
6 · The paper itself

Abstract

Activating Janus kinase (JAK) and signal transducer and activator of transcription (STAT) mutations have been discovered in many T-cell malignancies, including anaplastic lymphoma kinase (ALK)

Indexed as

Anaplastic Lymphoma KinaseAnimalsCell Line, TumorCell ProliferationCell SurvivalCytokine Receptor gp130CytokinesHumansJanus Kinase 1Lymphoma, Large-Cell, AnaplasticMiceNitrilesPhosphorylationPiperidinesProtein Kinase InhibitorsPyrazolesALK protein, humanAlk protein, mouseAnaplastic Lymphoma KinaseCytokine Receptor gp130CytokinesJAK1 protein, humanJanus Kinase 1NitrilesPiperidinesProtein Kinase InhibitorsPyrazolesPyrimidinesPyrrolesReceptor Protein-Tyrosine KinasesReceptors, CytokineruxolitinibSTAT3 protein, humanSTAT3 Transcription FactortofacitinibALK− ALCLcytokine receptorJAKmutationsSTAT

Identifiers

PMID28356514
PMCPMC5393253
OpenAlexW2603946503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.