Evidence map›Paper›PMID 28356511›Full record

ArticleScience translational medicine2017

Poly(GP) proteins are a useful pharmacodynamic marker for

Tania F Gendron, Jeannie Chew, Jeannette N Stankowski, Lindsey R Hayes, Yong-Jie Zhang, Mercedes Prudencio, Yari Carlomagno, Lillian M Daughrity, Karen Jansen-West, Emilie A Perkerson and 69 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 1 pooled it
22.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 1 synthesis or guideline pooled it, 266 citations in OpenAlex.

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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

79 authors at 20 institutions in 3 countries.

Tania F GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Jeannie ChewDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Jeannette N StankowskiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Lindsey R HayesBrain Science Institute and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
Yong-Jie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-9900-4313
Mercedes PrudencioDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-4894-4858
Yari CarlomagnoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5530-7737
Lillian M DaughrityDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Karen Jansen-WestDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Emilie A PerkersonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Aliesha O'RawDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-6618-3036
Casey CookDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Luc PregentDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-0840-618X
Veronique BelzilDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4450-5396
Marka van BlitterswijkDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3054-7053
Lilia J TabassianDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Chris W LeeDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Mei YueDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Jimei TongDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Yuping SongDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Monica Castanedes-CaseyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-8441-7801
Linda RousseauDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-1182-9629
Virginia PhillipsDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7751-2915
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Rosa RademakersDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-4049-0863
John D FryerDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Beth K RushDepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA.
Otto PedrazaDepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA.
Ana M CaputoDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Pamela DesaroDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-6846-0658
Carla PalmucciDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7749-1341
Amelia RobertsonDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-5534-305X
Michael G HeckmanSection of Biostatistics, Mayo Clinic, Jacksonville, FL 32224, USA.
Nancy N DiehlSection of Biostatistics, Mayo Clinic, Jacksonville, FL 32224, USA.
Edythe WiggsMotor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Michael TierneyMotor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Laura BraunMotor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Jennifer FarrenMotor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
David LacomisDepartments of Neurology and Pathology, University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0001-8646-943X
Shafeeq LadhaDepartments of Neurology and Neurobiology, Barrow Neurological Institute, Phoenix, AZ 85013, USA.ORCID 0000-0003-1955-4292
Christina N FournierDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Leo F McCluskeyDepartment of Neurology and the Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lauren B ElmanDepartment of Neurology and the Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jon B ToledoDepartment of Neurology, Houston Methodist Neurological Institute, Houston, TX 77030, USA.
Jennifer D McBrideCenter for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cinzia TilocaDepartment of Neurology-Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID 0000-0001-8491-5758
Claudia MorelliDepartment of Neurology-Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Barbara PolettiDepartment of Neurology-Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID 0000-0003-4398-2051
Federica SolcaDepartment of Neurology-Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID 0000-0002-3274-3963
Alessandro PrelleDepartment of Neurology and Stroke Unit, Ospedale Maggiore di Crema, Crema, Italy.ORCID 0000-0002-7019-5291
Joanne WuuDepartment of Neurology, University of Miami, Miami, FL 33136, USA.
Jennifer Jockel-BalsarottiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8079-7894
Frank RigoIonis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Christine AmbroseAleta Biotherapeutics, Natick, MA 01760, USA.
Abhishek DattaProtein Chemistry, Biogen Idec, Cambridge, MA 02142, USA.
Weixing YangProtein Chemistry, Biogen Idec, Cambridge, MA 02142, USA.ORCID 0000-0003-3772-1293
Denitza RaitchevaGlobal Biomarker and Drug Discovery, Biogen Idec, Cambridge, MA 02142, USA.ORCID 0000-0001-9003-9168
Giovanna AntognettiBiologics Drug Discovery, Biogen Idec, Cambridge, MA 02142, USA.
Alexander McCampbellNeurology Research, Biogen Idec, Cambridge, MA 02142, USA.
John C Van SwietenDepartment of Neurology, Erasmus MC, University Medical Centre, Rotterdam, Netherlands.
Bruce L MillerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Adam L BoxerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Robert H BrownDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Robert BowserDepartments of Neurology and Neurobiology, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Timothy M MillerDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
John Q TrojanowskiCenter for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Murray GrossmanDepartment of Neurology and the Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
James D BerryNeurological Clinical Research Institute, Massachusetts General Hospital, Boston, MA 02114, USA.
William T HuDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Antonia RattiDepartment of Neurology-Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Bryan J TraynorNeuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Matthew D DisneyDepartment of Chemistry, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
Michael BenatarDepartment of Neurology, University of Miami, Miami, FL 33136, USA.ORCID 0000-0003-4241-5135
Vincenzo SilaniDepartment of Neurology-Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID 0000-0002-7698-3854
Jonathan D GlassDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Mary Kay FloeterMotor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Jeffrey D RothsteinBrain Science Institute and Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.
Kevin B BoylanDepartment of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. petrucelli.leonard@mayo.edu.ORCID 0000-0003-2959-129X
Mayo Clinic in Florida · USWinnMed · USBiogen (United States) · USNational Institute of Neurological Disorders and Stroke · USIRCCS Istituto Auxologico Italiano · ITEmory University · USPennsylvania Academic Library Consortium · USBarrow Neurological Institute · USJohns Hopkins University · USUniversity of California, San Francisco · USUniversity of Miami · USUniversity of Milan · ITUniversity of Pennsylvania · USWashington University in St. Louis · USAzienda Ospedaliera Ospedale Maggiore · ITErasmus MC · NLHouston Methodist · USIonis Pharmaceuticals (United States) · USMassachusetts General Hospital · USNanotherapeutics (United States) · US

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
Uncovering new genes and disease modifiers for ALS and related disordersU54NS092091 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Michael Benatar · 2014 to 2026
$19.8M
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6M
Neuron and Glial Cellular Signatures from Normal and Diseased iPS Cells-SupplementU54NS091046 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI FINKBEINER, STEVEN M, FRAENKEL, ERNEST · 2014 to 2020
$11.7M
Expanding insights into FTD disease mechanismsR35NS097273 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2017 to 2024
$10.6M
Natural history and biomarker discovery in C9orf72 Amyotrophic lateral sclerosis and frontotemporal dementiaZIANS003146 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI FLOETER, MARY KAY · 2015 to 2020
$6.6M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Using a disease-affected cell to synthesize its own drugDP1NS096898 · NINDS · SCRIPPS FLORIDA · PI DISNEY, MATTHEW D · 2015 to 2019
$5.0M
Using motor neuron specific miRNA to understand and develop novel therapeutics for motor neuron diseaseR01NS078398 · NINDS · WASHINGTON UNIVERSITY · PI MILLER, TIMOTHY M. · 2012 to 2021
$3.9M
Research Education Program for Residents and Fellows in Neurology - PorrasR25NS065729 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2009 to 2024
$3.3M
Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Intramural NIH HHS Z01 AG000949NIA NIH HHS K23 AG042856NIA NIH HHS P01 AG017586NIA NIH HHS P30 AG010124NINDS NIH HHS DP1 NS096898NINDS NIH HHS P01 NS084974NINDS NIH HHS R01 NS078398NINDS NIH HHS R01 NS085207NINDS NIH HHS R01 NS088689NINDS NIH HHS R21 NS084528NINDS NIH HHS R21 NS089979NINDS NIH HHS R25 NS065729NINDS NIH HHS R35 NS097273NINDS NIH HHS U54 NS091046NINDS NIH HHS U54 NS092089NINDS NIH HHS U54 NS092091
6 · The paper itself

Abstract

There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. However, discovery of a G

Indexed as

AdultAgedAmyotrophic Lateral SclerosisAnimalsBiomarkersBrainC9orf72 ProteinCell LineDinucleotide RepeatsHumansInduced Pluripotent Stem CellsLeukocytes, MononuclearLongitudinal StudiesMiceMiddle AgedNeuronsBiomarkersC9orf72 ProteinOligonucleotides, AntisenseRNA

Identifiers

PMID28356511
PMCPMC5576451
OpenAlexW2599471352

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.