ArticleThe Journal of pharmacology and experimental therapeutics2017
Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis.
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Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Downregulation of osteoclast differentiation and activation by the soluble epoxide hydrolase inhibition.The Journal of pharmacology and experimental therapeutics · 2026Article
- The influence of soluble epoxide hydrolase inhibition and their PUFA-derived epoxides in osteoblast bone metabolism: an in vitro study.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025Article
- Soluble epoxide hydrolase inhibition impairs triggering receptor expressed on myeloid cells-1 in periodontal tissue.Journal of periodontal research · 2025Article
- Soluble epoxide hydrolase inhibition preserves alveolar bone in experimental periodontitis with estrogen deficiency.Frontiers in immunology · 2025Article
- Inhibition of soluble epoxide hydrolase reverses bone loss in periodontitis by upregulating EMCN and inhibiting osteoclasts.Stem cell research & therapy · 2024Article
- Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2024Article
- Modulating the sEH/EETs Axis Restrains Specialized Proresolving Mediator Impairment and Regulates T Cell Imbalance in Experimental Periodontitis.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis.International immunopharmacology · 2023Article
- Soluble epoxide hydrolase inhibition enhances production of specialized pro-resolving lipid mediator and promotes macrophage plasticity.British journal of pharmacology · 2023Article
- Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon.International journal of molecular sciences · 2023Article
- Aflatoxin BEcotoxicology and environmental safety · 2023Article
- The impact of the soluble epoxide hydrolase cascade on periodontal tissues.Frontiers in dental medicine · 2023Review
- Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint.Inflammopharmacology · 2022Article
- Targeting Soluble Epoxide Hydrolase and Cyclooxygenases Enhance Joint Pain Control, Stimulate Collagen Synthesis, and Protect Chondrocytes From Cytokine-Induced Apoptosis.Frontiers in veterinary science · 2021Article
- Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats.International immunopharmacology · 2020Article
- Article
- Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.Journal of lipid research · 2019Article
- Molecular changes in peripheral blood involving osteoarthritic joint remodelling.Journal of oral rehabilitation · 2019Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Carlos Antonio Trindade-da-SilvaDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Ahmed BettaiebDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Marcelo Henrique NapimogaDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Kin Sing Stephen LeeDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Bora InceogluDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Carlos Ueira-VieiraDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Donald BruunDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Sumanta Kumar GoswamiDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Fawaz G HajDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.).
Bruce D HammockDepartment of Entomology and Nematology and University of California, Davis Comprehensive Cancer Center (C.A.T.-S., K.S.S.L., B.I., S.K.G., B.D.H.), Nutrition Department (F.G.H.), and Department of Molecular Biosciences, School of Veterinary Medicine (D.B.), University of California, Davis, California; Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil (C.A.T.-d.-S., C.U.-V.); Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, Brazil (M.H.N.); and Department of Nutrition, University of Tennessee-Knoxville, Knoxville, Tennessee (A.B.) bdhammock@ucdavis.edu.
Universidade Federal de Uberlândia · BRUniversity of California, Davis · USUniversity of Tennessee at Knoxville · USFaculdade São Leopoldo Mandic · BR
Funding
Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1MUCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2MMouse Metabolic Phenotyping Center (MMPC) at UC DavisU2CDK092993 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2016 to 2021
$5.9MHYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0MRole of adipose protein-tyrosine phosphatase 1B in glucose homeostasis and body mR01DK090492 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAJ, FAWAZ GEORGE · 2011 to 2015
$1.7MsEH Inhibitors to Treat Neuropathic PainR44ES025598 · NIEHS · EICOSIS, LLC · PI BUCKPITT, ALAN R, HAMMOCK, BRUCE D · 2016 to 2017
$1.5MRole of T cell protein-tyrosine phosphatase in pancreatic islet functionR01DK095359 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAJ, FAWAZ GEORGE · 2014 to 2017
$1.4MMetabolic Functions of Adipose Pyruvate Kinase M2R00DK100736 · NIDDK · UNIVERSITY OF TENNESSEE KNOXVILLE · PI BETTAIEB, AHMED · 2015 to 2017
$736kIdentifying the receptors of environmentally sensitive epoxy-eicosanoids with AMSR00ES024806 · NIEHS · MICHIGAN STATE UNIVERSITY · PI LEE, KIN SING STEPHEN · 2017 to 2019
$727ksEH Inhibitors to Treat Neuropathic PainR43ES025598 · NIEHS · EICOSIS, LLC · PI BUCKPITT, ALAN R · 2014 to 2014
$224kNIDDK NIH HHS R00 DK100736NIDDK NIH HHS R01 DK090492NIDDK NIH HHS R01 DK095359NIDDK NIH HHS U2C DK092993NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R00 ES024806NIEHS NIH HHS R01 ES002710NIEHS NIH HHS R43 ES025598NIEHS NIH HHS R44 ES025598NIH HHS U42 OD012210
Abstract
Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid derived from the cytochrome P450 enzymes, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols. EETs but not their diols, have anti-inflammatory properties, and inhibition of sEH might provide protective effects against inflammatory bone loss. Thus, in the present study, we tested the selective sEH inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), in a mouse model of periodontitis induced by infection with
Indexed as
Alveolar Bone LossAnimalsApoptosisEndoplasmic Reticulum StressEpoxide HydrolasesInflammationInflammation MediatorsMaleMiceMice, Inbred C57BLMice, KnockoutPeriodontitisPhenylurea CompoundsPiperidinesReceptor Activator of Nuclear Factor-kappa BSignal Transduction1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)ureaEpoxide HydrolasesInflammation MediatorsPhenylurea CompoundsPiperidinesReceptor Activator of Nuclear Factor-kappa BTnfrsf11a protein, mouse
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