ArticleNeurology2017
Dopamine D2/D3 imbalance during migraine attack and allodynia in vivo.
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In one paragraph
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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32citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Practice advisory for intravenous management of headache disorders in hospitalized patients: a review of the evidence and consensus recommendations.Regional anesthesia and pain medicine · 2026Pooled it
- Trial
- Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system.NeuroImage. Clinical · 2019Trial
- Dopaminergic Dysregulation in Migraine: From Hypothalamic A11 Dysfunction to a Systemic Biobehavioral Phenotype.International journal of molecular sciences · 2026Review
- Mesocorticolimbic circuitry in episodic migraine: reward- and punishment-related responses and resting-state connectivity.The journal of headache and pain · 2026Article
- Identification of common genetic and molecular signatures in migraine and comorbid conditions.The journal of headache and pain · 2026Review
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Hispidulin Isolated from the Leaves of Clerodendrum inerme (L.) Gaertn Suppresses Trigeminovascular System Activation in a Rat Model Mimicking Migraine.Pharmaceutical research · 2025Article
- Bridging migraine and psychosis: a neuropsychiatric review of shared dopaminergic mechanisms.Frontiers in neurology · 2025Review
- Prevalence and features of headache in Parkinson's disease: the role of dopamine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Intervening in the Premonitory Phase to Prevent Migraine: Prospects for Pharmacotherapy.CNS drugs · 2024Review
- Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization.Antioxidants (Basel, Switzerland) · 2024Article
- Dopaminergic Projections from the Hypothalamic A11 Nucleus to the Spinal Trigeminal Nucleus Are Involved in Bidirectional Migraine Modulation.International journal of molecular sciences · 2023Article
- Meditation Practice, Mindfulness, and Pain-Related Outcomes in Mindfulness-Based Treatment for Episodic Migraine.Mindfulness · 2023Article
- Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings.International journal of molecular sciences · 2023Review
- Classifying migraine using PET compressive big data analytics of brain'sFrontiers in pharmacology · 2023Article
- Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache.Molecular and cellular biochemistry · 2022Review
- Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.The journal of headache and pain · 2022Article
- Patient Experience of Flunarizine for Vestibular Migraine: Single Centre Observational Study.Brain sciences · 2022Article
- Refractory migraine profile in CGRP-monoclonal antibodies scenario.Acta neurologica Scandinavica · 2021Article
Corrections and comments
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Authors and funding
14 authors.
Alexandre F DaSilvaFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor. adasilva@umich.edu.
Thiago D NascimentoFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Hassan JassarFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Joseph HeffernanFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Rebecca L TobackFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Sarah LucasFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Marcos F DosSantosFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Emily L BellileFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Philip S BoonstraFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Jeremy M G TaylorFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Kenneth L CaseyFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Robert A KoeppeFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Yolanda R SmithFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Jon-Kar ZubietaFrom the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Biostatistics (E.L.B., P.S.B., J.M.G.T.), Department of Neurology (K.L.C.), PET Physics Section, Division of Nuclear Medicine, Radiology Department (R.A.K.), and Department of Obstetrics and Gynecology (Y.R.S.), University of Michigan, Ann Arbor.
Funding
Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in vivo)R01NS094413 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALEXANDRE DASILVA · 2015 to 2026
$4.3MStructural and Molecular Neuroplasticity in Chronic Trigeminal PainK23NS062946 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2009 to 2013
$779kNINDS NIH HHS K23 NS062946NINDS NIH HHS R01 NS094413
Abstract
objectiveTo evaluate in vivo the dynamics of endogenous dopamine (DA) neurotransmission during migraine ictus with allodynia.
methodsWe examined 8 episodic migraineurs and 8 healthy controls (HC) using PET with [
resultsStriatal BP
conclusionsOur findings demonstrate that there is an imbalanced uptake of [
Indexed as
AdultBrainBrain MappingDopamineFemaleHot TemperatureHumansHyperalgesiaMaleMigraine with AuraMigraine without AuraPhysical StimulationPositron-Emission TomographyRacloprideRadiopharmaceuticalsReceptors, Dopamine D2DopamineDRD2 protein, humanDRD3 protein, humanRacloprideRadiopharmaceuticalsReceptors, Dopamine D2Receptors, Dopamine D3
Identifiers
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