Evidence map›Paper›PMID 28356460›Full record

ArticleNeurology2017

Impaired intracortical inhibition demonstrated in vivo in people with Dravet syndrome.

William M Stern, Josemir W Sander, John C Rothwell, Sanjay M Sisodiya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  8. Article
  9. Review
  10. Natural History Studies and Clinical Trial Readiness for Genetic Developmental and Epileptic Encephalopathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  11. Review
  12. Article
  13. Drug repositioning in epilepsy reveals novel antiseizure candidates.Annals of clinical and translational neurology · 2019
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William M SternFrom the Department of Clinical and Experimental Epilepsy, NIHR University College London Hospitals Biomedical Research Centre (W.M.S., J.W.S., S.M.S.), and Sobell Department of Motor Neuroscience and Movement Disorders (J.C.R.), UCL Institute of Neurology; Epilepsy Society (W.M.S., J.W.S., S.M.S.), Chalfont St Peter, UK; and Stichting Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands.
Josemir W SanderFrom the Department of Clinical and Experimental Epilepsy, NIHR University College London Hospitals Biomedical Research Centre (W.M.S., J.W.S., S.M.S.), and Sobell Department of Motor Neuroscience and Movement Disorders (J.C.R.), UCL Institute of Neurology; Epilepsy Society (W.M.S., J.W.S., S.M.S.), Chalfont St Peter, UK; and Stichting Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands.
John C RothwellFrom the Department of Clinical and Experimental Epilepsy, NIHR University College London Hospitals Biomedical Research Centre (W.M.S., J.W.S., S.M.S.), and Sobell Department of Motor Neuroscience and Movement Disorders (J.C.R.), UCL Institute of Neurology; Epilepsy Society (W.M.S., J.W.S., S.M.S.), Chalfont St Peter, UK; and Stichting Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands.
Sanjay M SisodiyaFrom the Department of Clinical and Experimental Epilepsy, NIHR University College London Hospitals Biomedical Research Centre (W.M.S., J.W.S., S.M.S.), and Sobell Department of Motor Neuroscience and Movement Disorders (J.C.R.), UCL Institute of Neurology; Epilepsy Society (W.M.S., J.W.S., S.M.S.), Chalfont St Peter, UK; and Stichting Epilepsie Instellingen Nederland (SEIN) (J.W.S.), Heemstede, the Netherlands. s.sisodiya@ucl.ac.uk.

Funding

Medical Research Council G0500258Medical Research Council MR/P006671/1
6 · The paper itself

Abstract

objectiveDravet syndrome is a rare neurodevelopmental disorder characterized by seizures and other neurologic problems.

methodsTranscranial magnetic stimulation using single and paired pulse paradigms was applied to people with Dravet syndrome and to 2 control groups to study motor cortex excitability.

resultsShort interval intracortical inhibition (SICI), which measures GABAergic inhibitory network behavior, was undetectable in Dravet syndrome, but detectable in all controls. Other paradigms, including those testing excitatory networks, showed no difference between Dravet and control groups.

conclusionsThere were marked differences in inhibitory networks, detected using SICI paradigms, while other inhibitory and excitatory paradigms yielded normal results. These human data showing reduced GABAergic inhibition in vivo in people with Dravet syndrome support established animal models.

Indexed as

AdultAnalysis of VarianceEpilepsies, MyoclonicFemalegamma-Aminobutyric AcidHumansMaleMiddle AgedMotor CortexMovementMutationNAV1.1 Voltage-Gated Sodium ChannelNeural InhibitionNeural PathwaysSurveys and QuestionnairesTranscranial Magnetic Stimulationgamma-Aminobutyric AcidNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, human

Identifiers

PMID28356460
PMCPMC5405762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.