Evidence map›Paper›PMID 28356433›Full record

ArticleThe Journal of nutrition2017

Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC).

M Kyla Shea, Sarah L Booth, Daniel E Weiner, Tina E Brinkley, Alka M Kanaya, Rachel A Murphy, Eleanor M Simonsick, Christina L Wassel, Cees Vermeer, Stephen B Kritchevsky and 1 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The Journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06250647 (Effect of Dietary Intervention With a High Intake of Vitamin K on Insulin, Osteocalcin, Leptin, Vitamin K Serum Levels and Cardiovascular Risk in Young Adults With and Without Overweight or Obesity.), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06250647 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of Dietary Intervention With a High Intake of Vitamin K on Insulin, Osteocalcin, Leptin, Vitamin K Serum Levels and Cardiovascular Risk in Young Adults With and Without Overweight or Obesity.

TypeinterventionalSponsorUniversity of GuadalajaraRan2021 to 2021Enrolled72ConditionsOverweight and ObesityArmsvitamin K diet
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Vitamin K and women's health: a review.Frontiers in global women's health · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Vitamin KOpen heart · 2021
    Review
  12. Review
  13. Review
  14. Article
  15. Olfaction and Changes in Body Composition in a Large Cohort of Older U.S. Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  16. Article
  17. Article
  18. Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  19. Serum vitamin KBMJ open diabetes research & care · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

M Kyla SheaUSDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA; kyla.shea@tufts.edu.
Sarah L BoothUSDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
Daniel E WeinerDivision of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA.
Tina E BrinkleySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC.
Alka M KanayaUniversity of California-San Francisco, San Francisco, CA.
Rachel A MurphySchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Eleanor M SimonsickNational Institute on Aging/NIH, Baltimore, MD.
Christina L WasselGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; and.
Cees VermeerVitaK, University of Maastricht, Maastricht, Netherlands.
Stephen B KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC.
Health ABC Study
Tufts University · USWake Forest University · USMaastricht University · NLNational Institute on Aging · USTufts Medical Center · USUniversity of British Columbia · CAUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101N01AG062101 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2004
$996k
DYNAMICS OF HEALTH . AGING . AND BODY COMPOSITION /Memphis/-26062103N01AG062103 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 1996 to 2004
$793k
Identifying Vitamin K Dependent Pathways in Osteoarthritis ProgressionK01AR063167 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHEA, MARY KYLA · 2012 to 2015
$455k
Vitamin K, Knee Osteoarthritis, and Physical Function in Older AdultsR21AR062284 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRITCHEVSKY, STEPHEN B., LOESER, RICHARD F · 2012 to 2013
$370k
HEALTH ABC--COORDINATING UNIT /California/-260062106N01AG062106 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1996 to 2004
$109k
NIAMS NIH HHS K01 AR063167NIAMS NIH HHS R21 AR062284NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG028050NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAgingAntihypertensive AgentsAvitaminosisBody CompositionCalcinosisCalcium-Binding ProteinsCardiovascular DiseasesExtracellular Matrix ProteinsFemaleHumansHypertensionMaleMatrix Gla ProteinMyocardial InfarctionMyocardial IschemiaAntihypertensive AgentsCalcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla ProteinVitamin K 1cardiovascular diseasehypertensionmatrix Gla proteinphylloquinonevitamin K

Identifiers

PMID28356433
PMCPMC5404216
OpenAlexW2602271402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.