ArticleCirculation research2017
Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease.
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Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Authors and funding
11 authors at 1 institution in 1 country.
Alanna WatsonFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Zengxuan NongFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Hao YinFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Caroline O'NeilFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Stephanie FoxFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Brittany BalintFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Linrui GuoFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Oberdan LeoFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Michael W A ChuFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
Robert GrosFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.).
J Geoffrey PickeringFrom the Robarts Research Institute (A.W., Z.N., H.Y., C.O., R.G., J.G.P.), Division of Cardiology, Department of Medicine (J.G.P.), Department of Biochemistry (A.W., J.G.P.), Department of Medical Biophysics (B.B., J.G.P.), Department of Surgery (S.F., L.G., M.W.A.C.), and Department of Physiology and Pharmacology (R.G.), The University of Western Ontario, London Health Sciences Centre, Canada; and Department of Molecular Biology, Université Libre de Bruxelles, Gosselies, Belgium (O.L.). gpickering@robarts.ca.
Western University · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe thoracic aortic wall can degenerate over time with catastrophic consequences. Vascular smooth muscle cells (SMCs) can resist and repair artery damage, but their capacities decline with age and stress. Recently, cellular production of nicotinamide adenine dinucleotide (NAD
objectivesTo determine whether a Nampt-NAD METHODS AND
resultsAscending aortas from patients with dilated aortopathy were immunostained for NAMPT, revealing an inverse relationship between SMC NAMPT content and aortic diameter. To determine whether a Nampt-NAD
conclusionsThe aortic media depends on an intrinsic NAD
Indexed as
AdultAgedAnimalsAortaAortic Aneurysm, ThoracicCells, CulturedCytokinesDNA DamageFemaleGenomeHumansLaser Capture MicrodissectionMaleMiceMice, KnockoutMiddle AgedCytokinesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humannicotinamide phosphoribosyltransferase, mouseaortic diseasecell agingDNA damageextracellular matrix
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