ArticleMolecular & general genetics : MGG1988
An AT rich region of dyad symmetry is a promoter element in the yeast TRP1 gene.
Article in Molecular & general genetics : MGG, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 7 citations in OpenAlex.
- The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription.Nucleic acids research · 2005Article
- Multifunctional centromere binding factor 1 is essential for chromosome segregation in the human pathogenic yeast Candida glabrata.Molecular and cellular biology · 2001Article
- Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.Microbiological reviews · 1991Review
- DNA binding of CPF1 is required for optimal centromere function but not for maintaining methionine prototrophy in yeast.Nucleic acids research · 1991Article
- Transcriptional activation by upstream activator sequences requires distinct interactions with downstream elements in the yeast TRP1 promoter.Molecular & general genetics : MGG · 1991Article
- CPF1, a yeast protein which functions in centromeres and promoters.The EMBO journal · 1990Article
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4 authors at 1 institution in 1 country.
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Abstract
Transcription from the yeast TRP1 promoter results in two classes of transcript, I and II, that are influenced by different promoter elements. The 5' flanking region contains a region of dyad symmetry (RDS) which contains a 12 nucleotide AT rich inverted repeat, separated by a 21 bp spacer region. The RDS lies within a region of the promoter required for transcription of class II RNAs. A series of internal deletions and insertions have been constructed in vitro around the RDS and the effect of each mutation on transcription has been analysed. Deleting either of the repeats abolishes class II transcription and disruption of both repeats influenced the levels of the larger class I transcripts. Deletion of the spacer had no effect but increasing the length to 33 bp reduced transcription. These results show that the RDS is an important component of the TRP1 promoter, that both repeats must be preserved and that there is some constraint on the spacing of the repeats for maximal function.
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