ArticleGenome research2017
Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice.
Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
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- SPREd: A simulation-supervised neural network tool for gene regulatory network reconstruction.bioRxiv : the preprint server for biology · 2023Article
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- Multifaceted Transcriptional Network of Estrogen-Related Receptor Alpha in Health and Disease.International journal of molecular sciences · 2023Review
- Galnt17 loss-of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology.Developmental biology · 2022Article
- Brain transcriptome analysis reveals gene expression differences associated with dispersal behaviour between range-front and range-core populations of invasive cane toads in Australia.Molecular ecology · 2022Article
- An epigenomic shift in amygdala marks the transition to maternal behaviors in alloparenting virgin female mice.PloS one · 2022Article
- Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain.Neuroscience · 2021Article
- Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps.PLoS genetics · 2021Article
- Transcriptional Regulation of ROS Homeostasis by the ERR Subfamily of Nuclear Receptors.Antioxidants (Basel, Switzerland) · 2021Review
- Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks.eLife · 2020Article
- Behavior-related gene regulatory networks: A new level of organization in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Biological embedding of experience: A primer on epigenetics.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Subregion-specific rules govern the distribution of neuronal immediate-early gene induction.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens.PLoS genetics · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Agonistic encounters are powerful effectors of future behavior, and the ability to learn from this type of social challenge is an essential adaptive trait. We recently identified a conserved transcriptional program defining the response to social challenge across animal species, highly enriched in transcription factor (TF), energy metabolism, and developmental signaling genes. To understand the trajectory of this program and to uncover the most important regulatory influences controlling this response, we integrated gene expression data with the chromatin landscape in the hypothalamus, frontal cortex, and amygdala of socially challenged mice over time. The expression data revealed a complex spatiotemporal patterning of events starting with neural signaling molecules in the frontal cortex and ending in the modulation of developmental factors in the amygdala and hypothalamus, underpinned by a systems-wide shift in expression of energy metabolism-related genes. The transcriptional signals were correlated with significant shifts in chromatin accessibility and a network of challenge-associated TFs. Among these, the conserved metabolic and developmental regulator ESRRA was highlighted for an especially early and important regulatory role. Cell-type deconvolution analysis attributed the differential metabolic and developmental signals in this social context primarily to oligodendrocytes and neurons, respectively, and we show that ESRRA is expressed in both cell types. Localizing ESRRA binding sites in cortical chromatin, we show that this nuclear receptor binds both differentially expressed energy-related and neurodevelopmental TF genes. These data link metabolic and neurodevelopmental signaling to social challenge, and identify key regulatory drivers of this process with unprecedented tissue and temporal resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.