ArticleJournal of the American Heart Association2017
Sex- and Race-Related Differences in Characteristics and Outcomes of Hospitalizations for Heart Failure With Preserved Ejection Fraction.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- Sex-Based Differences in Management and Outcomes of Patients Admitted or Transferred to Advanced Therapy Centers for Heart Failure.Journal of clinical medicine · 2026Article
- Mortality trends involving fatal-arrhythmias and anemia in the United States: A retrospective analysis of 25 years.Medicine · 2026Observational
- Clinical Pharmacology of Heart Failure in Frailty.European cardiology · 2026Review
- Demographic disparities in heart failure with preserved ejection fraction.Heart failure reviews · 2025Review
- Underpinnings of heart failure with preserved ejection fraction in women - From prevention to improving function. A co-publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure.American journal of preventive cardiology · 2025Article
- Gender-Specific Differences in Diastolic Dysfunction and HFpEF: Pathophysiology, Diagnosis, and Therapeutic Strategies.Journal of cardiovascular development and disease · 2025Review
- Current anti-inflammatory strategies for treatment of heart failure: From innate to adaptive immunity.Pharmacological research · 2025Review
- Growth differentiation factor-15 and N-terminal pro-BNP in acute heart failure with preserved ejection fraction.ESC heart failure · 2025Observational
- Housing temperature influences metabolic phenotype of heart failure with preserved ejection fraction in J vs N strain C57BL/6 mice.Molecular and cellular endocrinology · 2025Article
- Sex disparities in outcomes among hospitalizations for heart failure.Scientific reports · 2024Article
- Race- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing.JACC. Advances · 2024Article
- Lagging behind the Western countries: the knowledge gaps of gender differences in heart failure in Asia.ESC heart failure · 2023Review
- Renal Denervation Helps Preserve the Ejection Fraction by Preserving Endocardial-Endothelial Function during Heart Failure.International journal of molecular sciences · 2023Article
- Evaluation of large animal models for preclinical studies of heart failure with preserved ejection fraction using clinical score systems.Frontiers in cardiovascular medicine · 2023Review
- Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions.BMC medicine · 2022Review
- Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models.JACC. Basic to translational science · 2022Review
- Sex differences in acute cardiovascular care: a review and needs assessment.Cardiovascular research · 2022Review
- Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: Pathophysiology, Assessment, Prevalence and Prognosis.Cardiac failure review · 2022Review
- Spatial Distribution of Mortality for Heart Failure in Brazil, 1996 - 2017.Arquivos brasileiros de cardiologia · 2022Article
- Mitigating Racial Bias in Machine Learning.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSex and race have emerged as important contributors to the phenotypic heterogeneity of heart failure with preserved ejection fraction (HFpEF). However, there remains a need to identify important sex- and race-related differences in characteristics and outcomes using a nationally representative cohort. METHODS AND
resultsData were obtained from the Agency for Healthcare Research and Quality Healthcare Cost and Utilization Project-Nationwide Inpatient Sample files between 2008 and 2012. Hospitalizations with a diagnosis of HFpEF were included for analysis. Demographics, hospital characteristics, and age-adjusted comorbidity prevalence rates were compared between men and women and whites and blacks. In-hospital mortality was determined and compared for each subgroup. Multivariable regression analyses were used to identify and compare correlates of in-hospital mortality for each subgroup. A sample of 1 889 608 hospitalizations was analyzed. Men with HFpEF were slightly younger than women with HFpEF and had a higher Elixhauser comorbidity score. Men experienced higher in-hospital mortality compared with women, a finding that was attenuated after adjusting for comorbidity. Blacks with HFpEF were younger than whites with HFpEF, with lower rates of most comorbidities. Hypertension, diabetes, anemia, and chronic renal failure were more common among blacks. Blacks experienced lower in-hospital mortality compared with whites, even after adjusting for age and comorbidity. Important correlates of mortality among all 4 subgroups included pulmonary circulation disorders, liver disease, and chronic renal failure. Atrial fibrillation was an important correlate of mortality only among women and blacks.
conclusionsDifferences in patient characteristics and outcomes reinforce the notion that sex and race contribute to the phenotypic heterogeneity of HFpEF.
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Registered trials
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