Evidence map›Paper›PMID 28356223›Full record

ArticleMolecular and biochemical parasitology2017

The role of the PI(3,5)P

Julia K Gilden, Khan Umaer, Emilia K Kruzel, Oliver Hecht, Renan O Correa, John M Mansfield, James D Bangs

Abstract read
In one paragraph

Article in Molecular and biochemical parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. To the Surface and Back: Exo- and Endocytic Pathways inFrontiers in cell and developmental biology · 2021
    Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia K GildenDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: julia.gilden@gmail.com.
Khan UmaerDepartment of Microbiology Immunology, School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY, USA. Electronic address: khanumae@buffalo.edu.
Emilia K KruzelDepartment of Microbiology Immunology, School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY, USA. Electronic address: emiliakr@buffalo.edu.
Oliver HechtDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: ohecht@wisc.edu.
Renan O CorreaDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: renanocorrea@gmail.com.
John M MansfieldDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: john.mansfield@wisc.edu.
James D BangsDepartment of Microbiology Immunology, School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY, USA. Electronic address: jdbangs@buffalo.edu.

Funding

Lysosomal biogenesis &function in African trypanosomesR01AI056866 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BANGS, JAMES D. · 2003 to 2015
$3.3M
NIAID NIH HHS R01 AI056866
6 · The paper itself

Abstract

Protein trafficking through endo/lysosomal compartments is critically important to the biology of the protozoan parasite Trypanosoma brucei, but the routes material may take to the lysosome, as well as the molecular factors regulating those routes, remain incompletely understood. Phosphoinositides are signaling phospholipids that regulate many trafficking events by recruiting specific effector proteins to discrete membrane subdomains. In this study, we investigate the role of one phosphoinositide, PI(3,5)P

Indexed as

EndosomesLysosomesPhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Protein TransportTrypanosoma brucei bruceiphosphatidylinositol 3,5-diphosphatePhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)EndosomeInvariant surface protein 6LysosomePI(3,5)P(2)Trypanosome

Identifiers

PMID28356223
PMCPMC5474170

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.