ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2017
Upper Airway Reflexes are Preserved During Dexmedetomidine Sedation in Children With Down Syndrome and Obstructive Sleep Apnea.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01902407 (Dynamic Computational Modeling of Obstructive Sleep Apnea in Down Syndrome), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dynamic Computational Modeling of Obstructive Sleep Apnea in Down Syndrome
Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Comparison of upper airway patency in patients with mild obstructive sleep apnea during dexmedetomidine or propofol sedation: a prospective, randomized, controlled trial.BMC anesthesiology · 2018Trial
- Dexmedetomidine Dosing Strategies in Sedation and Anesthesia: Pharmacokinetics, Safety, and Clinical Applications - A Narrative Review.Drug design, development and therapy · 2026Review
- Quantifying Neuromuscular and Pressure Force Dynamics in Obstructive Sleep Apnea: A Novel Computational Fluid Dynamics Approach Using Airway Wall Acceleration.Journal of biomechanical engineering · 2025Article
- Intranasal Dexmedetomidine Administration Precipitates Respiratory Failure in Child With Croup and Asthma.Clinical case reports · 2024Article
- The interaction between neuromuscular forces, aerodynamic forces, and anatomical motion in the upper airway predicts the severity of pediatric OSA.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The Effect of Dexmedetomidine Sedation on Lower Gastrointestinal Motility in Children-Is It Suitable for Anorectal Manometry?Journal of clinical medicine · 2023Article
- Phase-Contrast Magnetic Resonance Imaging of Inhaled Xenon Reveals the Relationship between Airflow and Obstruction in Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2023Article
- Article
- Predicting critical closing pressure in children with obstructive sleep apnea using fluid-structure interaction.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Propofol versus dexmedetomidine during drug-induced sleep endoscopy (DISE) for pediatric obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2021Article
- Effectiveness of pediatric drug-induced sleep endoscopy for REM-predominant obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2020Article
- Effects on the Upper Airway Morphology with Intravenous Addition of Ketamine after Dexmedetomidine Administration in Normal Children.Journal of clinical medicine · 2020Article
- Dexmedetomidine: What's New for Pediatrics? A Narrative Review.Journal of clinical medicine · 2020Review
- Protective effects of dexmedetomidine on lung in rats with one-lung ventilation.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesThe assessment of pharyngeal collapsibility is difficult to perform in children under normal sleep. An alternative is to perform the assessment under an anesthetic, such as dexmedetomidine (DEX), that induces non-rapid eye movement (NREM) sleep. The objectives of this study were to compare critical closing airway pressure (Pcrit) obtained during natural sleep to that obtained under DEX in patients with Down syndrome (DS) and persistent obstructive sleep apnea (OSA) and determine whether Pcrit measured under sedation predicts the severity of OSA.
methodsThe passive and active Pcrit, which represent airway passive mechanical properties and active dynamic responses to airway obstruction, respectively, were measured. Upper airway reflex activity was estimated by calculating the difference between active and passive Pcrit. Subjects underwent overnight polysomnography during which Pcrit was measured during normal sleep. Pcrit was also measured during DEX sedation at a dose of 2 μg/kg/h.
resultsThe study included 50 patients with median age of 11.4 years (interquartile range: 7.0-13.9) and median body mass index of 23.0 kg/m
conclusionPatients with OSA can compensate for airway obstruction under DEX-induced sleep. The close association between Pcrit and apnea-hypopnea index suggests that airway responses with DEX sedation parallel those seen during natural sleep. CLINICAL
trial registrationClinicalTrials.gov identifier: NCT01902407.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.