Evidence map›Paper›PMID 28356165›Full record

ArticleBMC research notes2017

Relationship between hyperglycemia, antioxidant capacity and some enzymatic and non-enzymatic antioxidants in African patients with type 2 diabetes.

Constant Anatole Pieme, Jérôme Antony Tatangmo, Gustave Simo, Prosper Cabral Biapa Nya, Vicky Jocelyne Ama Moor, Bruno Moukette Moukette, Francine Tankeu Nzufo, Borgia Legrand Njinkio Nono, Eugene Sobngwi

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 84 citations in OpenAlex.

  1. Cadmium-Induced Oxidative Stress Impairs Glycemic Control in Adolescents.Oxidative medicine and cellular longevity · 2017
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  4. Antioxidant and Anti-Inflammatory Benefits ofAntioxidants (Basel, Switzerland) · 2025
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  14. Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy.International journal of molecular sciences · 2022
    Review
  15. Plants (Basel, Switzerland) · 2022
    Review
  16. Ameliorative effects ofSaudi journal of biological sciences · 2022
    Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Constant Anatole PiemeDepartment of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon. apieme@yahoo.fr.ORCID http://orcid.org/0000-0003-1602-6494
Jérôme Antony TatangmoDepartment of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Gustave SimoDepartment of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Prosper Cabral Biapa NyaDepartment of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Vicky Jocelyne Ama MoorDepartment of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
Bruno Moukette MouketteDepartment of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
Francine Tankeu NzufoDepartment of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
Borgia Legrand Njinkio NonoDepartment of Biochemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
Eugene SobngwiDepartment of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box 1364, Yaounde, Cameroon.
Université de Yaoundé I · CMUniversité de Dschang · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeStudies demonstrate that free radicals are involved in the pathogenesis of diabetic complications. The aim of this study was to determine the implication of total antioxidant capacity (TAC) and some enzymatic and non-enzymatic antioxidants as suitable biomarkers of diabetic complications risk factors.

methodsA total of 90 patients (70 patients with or without diabetic complications +20 normal healthy) were examined by evaluating the level of lipid peroxidation, nitrogen monoxide (NO), fasting blood glucose, glycated haemoglobin (HbA1c), enzymatic and non-enzymatic antioxidants using standard spectrophotometric methods.

resultsThe fasting blood glucose and HbA1c levels were respectively 2.05 and 2.32 times higher in the group of patients with diabetes and complications (DPWC) compared to those of healthy persons. A statistically higher level of malondialdehyde (MDA), NO and TAC was observed in a group of patients with diabetes and complications compared to those without complications (DPNC). A significant positive correlation was found between catalase (CAT) and fasting blood glucose while a significant and negative correlation was noted between reduced glutathione (GSH) and fasting blood glucose. Also was noted a significant relationship between HbA1c and other markers of oxidative stress.

conclusionsThe results suggest that the plasma levels of CAT, TAC and reduced glutathione could give information on the risk of developing complications of diabetes, considering that the modification of these biomarkers levels were associated with oxidative stress.

Indexed as

AdultAgedAntioxidantsBiomarkersBlood GlucoseCameroonCatalaseDiabetes Mellitus, Type 2FastingFemaleGlutathioneGlycated HemoglobinHumansHyperglycemiaLipid PeroxidationMaleAntioxidantsBiomarkersBlood GlucoseCatalaseGlutathioneGlycated HemoglobinMalondialdehydeNitric OxideSuperoxide DismutaseMalondialdehydeOxidative stressTotal Antioxidant CapacityType 2 diabetes

Identifiers

PMID28356165
PMCPMC5372257
OpenAlexW2601313168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.