Evidence map›Paper›PMID 28356142›Full record

Trial reportBMC pediatrics2017

Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) - study design and methods of a randomised controlled double-blinded intervention study.

Otto Helve, Heli Viljakainen, Elisa Holmlund-Suila, Jenni Rosendahl, Helena Hauta-Alus, Maria Enlund-Cerullo, Saara Valkama, Kati Heinonen, Katri Räikkönen, Timo Hytinantti and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01723852 (Vitamin D Intervention in Infants), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01723852 nacompletednot on this map

Vitamin D Intervention in Infants

TypeinterventionalSponsorHelsinki University Central HospitalRan2013 to 2017Enrolled1,000ConditionsVitamin D StatusArmsVitamin D at 30 ug/day, Vitamin D at 10 ug/day
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  15. Collagen X Biomarker (CXM), Linear Growth, and Bone Development in a Vitamin D Intervention Study in Infants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Otto HelveChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland. otto.helve@helsinki.fi.ORCID 0000-0001-6254-3180
Heli ViljakainenChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Elisa Holmlund-SuilaChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Jenni RosendahlChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Helena Hauta-AlusChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Maria Enlund-CerulloChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Saara ValkamaChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Kati HeinonenInstitute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
Katri RäikkönenInstitute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
Timo HytinanttiChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Outi MäkitieChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
Sture AnderssonChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, P.O. Box 281, 00029 HUS, Helsinki, Finland.
University of Helsinki · FIKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D is important for bone mass accrual during growth. Additionally, it is considered a requirement for a multitude of processes associated with, for example, the development of immunity. Many countries apply vitamin D supplementation strategies in infants, but the guidelines are not based on scientific evidence and aim at prevention of rickets. It remains unclear whether the recommended doses are sufficient for the wide array of other effects of vitamin D. The VIDI trial performed in Finland is the first large randomised controlled study for evaluation of the effects of different vitamin D supplemental doses in infancy on: 1. bone strength 2. infections and immunity 3. allergy, atopy and asthma 4. cognitive development 5. genetic regulation of mineral homeostasis METHODS/

designVIDI, a randomised controlled double-blinded single-centre intervention study is conducted in infants from the age of 2 weeks to 24 months. Participants, recruited at Helsinki Maternity Hospital, are randomised to receive daily either 10 μg (400 IU) or 30 μg (1 200 IU) of vitamin D3 supplementation. Both groups are assessed at 6 months of age for calcium homeostasis, and at 12 and 24 months of age for parameters associated with bone strength, growth, developmental milestones, infections, immunity, atopy-related diseases, and genetic factors involved in these functions. DISCUSSION: The study enables evaluation of short and long term effects of supplemental vitamin D on growth, immune functions and skeletal and developmental parameters in infants, and the effects of genetic factors therein. The results enable institution of evidence-based guidelines for vitamin D supplementation in infancy.

trial registrationClinicalTrials.gov, NCT01723852 , registration date 6.11.2012.

Indexed as

Bone DevelopmentChild DevelopmentChild, PreschoolCholecalciferolClinical ProtocolsDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleEvidence-Based MedicineFemaleHumansImmune SystemInfantInfant, NewbornMaleCholecalciferolVitaminsAllergyAsthmaBone developmentCognitive developmentImmunityInfantsInfectionsVitamin D

Identifiers

PMID28356142
PMCPMC5372327
OpenAlexW2602641292

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.