Evidence map›Paper›PMID 28355965›Full record

ArticleTechnology in cancer research & treatment2017

Long Noncoding RNA PVT1 Promotes EMT and Cell Proliferation and Migration Through Downregulating p21 in Pancreatic Cancer Cells.

Bao-Qiang Wu, Yong Jiang, Feng Zhu, Dong-Lin Sun, Xiao-Zhou He

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. lncRNA PVT1: a novel oncogene in multiple cancers.Cellular & molecular biology letters · 2022
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. The role of splicing factor PRPF8 in breast cancer.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bao-Qiang WuDepartment of Hepatatobiliary Surgery, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu Province, China.
Yong JiangDepartment of Hepatatobiliary Surgery, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu Province, China.
Feng ZhuDepartment of Hepatatobiliary Surgery, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu Province, China.
Dong-Lin SunDepartment of Hepatatobiliary Surgery, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu Province, China.
Xiao-Zhou HeDepartment of Hepatatobiliary Surgery, The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu Province, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimLong noncoding RNA-plasmacytoma variant translocation 1 is identified to be highly expressed and exhibits oncogenic activity in a variety of human malignancies, including pancreatic cancer. However, little is known about the overall biological role and mechanism of plasmacytoma variant translocation 1 in pancreatic cancer so far. In this study, we investigated the effect of plasmacytoma variant translocation 1 on pancreatic cancer cell proliferation and migration as well as epithelial-mesenchymal transition.

methodsPancreatic cancer tissue specimens and cell line were used in this study, with normal tissue and cell line acting as control.

resultsIt showed that plasmacytoma variant translocation 1 expression was significantly upregulated in pancreatic cancer tissues or cell line compared to normal groups. Plasmacytoma variant translocation 1 downregulation significantly inhibited zinc finger E-box-binding protein 1/Snail expression but promoted p21 expression, and it also inhibited the cell proliferation and migration. Additionally, p21 downregulation enhanced, and p21 overexpression repressed, zinc finger E-box-binding protein 1/Snail expression and cells proliferation in PANC-1 cells. However, p21 downregulation reversed the effect of plasmacytoma variant translocation 1 downregulation on zinc finger E-box-binding protein 1/Snail expression and cell proliferation and migration.

conclusionPlasmacytoma variant translocation 1 promoted epithelial-mesenchymal transition and cell proliferation and migration through downregulating p21 in pancreatic cancer cells.

Indexed as

EMTlncRNAp21pancreatic cancerPVT1

Identifiers

PMID28355965
PMCPMC5762037
OpenAlexW2599990484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.