Evidence map›Paper›PMID 28355964›Full record

ArticleTechnology in cancer research & treatment2017

Study of Image Qualities From 6D Robot-Based CBCT Imaging System of Small Animal Irradiator.

Sunil Sharma, Ganesh Narayanasamy, Richard Clarkson, Ming Chao, Eduardo G Moros, Xin Zhang, Yulong Yan, Marjan Boerma, Nava Paudel, Steven Morrill and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Technology in cancer research & treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Sunil SharmaDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Ganesh NarayanasamyDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Richard ClarksonDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Ming ChaoDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Eduardo G MorosDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Xin ZhangDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Yulong YanDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Marjan BoermaDepartment of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Nava PaudelDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Steven MorrillDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Peter CorryDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Robert J GriffinDepartment of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USMoffitt Cancer Center · USThe University of Texas Southwestern Medical Center · US

Funding

The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI WOLFE, TATIANA · 2015 to 2024
$21.1M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
NCATS NIH HHS UL1 TR000039NIGMS NIH HHS P20 GM109005
6 · The paper itself

Abstract

purposeTo assess the quality of cone beam computed tomography images obtained by a robotic arm-based and image-guided small animal conformal radiation therapy device. METHOD AND MATERIALS: The small animal conformal radiation therapy device is equipped with a 40 to 225 kV X-ray tube mounted on a custom made gantry, a 1024 × 1024 pixels flat panel detector (200 μm resolution), a programmable 6 degrees of freedom robot for cone beam computed tomography imaging and conformal delivery of radiation doses. A series of 2-dimensional radiographic projection images were recorded in cone beam mode by placing and rotating microcomputed tomography phantoms on the "palm' of the robotic arm. Reconstructed images were studied for image quality (spatial resolution, image uniformity, computed tomography number linearity, voxel noise, and artifacts).

resultsGeometric accuracy was measured to be 2% corresponding to 0.7 mm accuracy on a Shelley microcomputed tomography QA phantom. Qualitative resolution of reconstructed axial computed tomography slices using the resolution coils was within 200 μm. Quantitative spatial resolution was found to be 3.16 lp/mm. Uniformity of the system was measured within 34 Hounsfield unit on a QRM microcomputed tomography water phantom. Computed tomography numbers measured using the linearity plate were linear with material density (

conclusionResults showed that the small animal conformal radiation therapy device is capable of producing high-quality cone beam computed tomography images for precise and conformal small animal dose delivery. With its high-caliber imaging capabilities, the small animal conformal radiation therapy device is a powerful tool for small animal research.

Indexed as

CBCTimaging QAmicroCTsmall animal imagingsmall animal irradiator

Identifiers

PMID28355964
PMCPMC5762036
OpenAlexW2603268904

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.