Evidence map›Paper›PMID 28355926›Full record

ArticleAIDS care2017

Role of male partner involvement in ART retention and adherence in Malawi's Option B+ program.

Austin Wesevich, Tiwonge Mtande, Friday Saidi, Elizabeth Cromwell, Hannock Tweya, Mina C Hosseinipour, Irving Hoffman, William C Miller, Nora E Rosenberg

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Austin Wesevicha UNC Project , University of North Carolina at Chapel Hill , Lilongwe , Malawi.ORCID 0000-0001-5202-1231
Tiwonge Mtandea UNC Project , University of North Carolina at Chapel Hill , Lilongwe , Malawi.
Friday Saidia UNC Project , University of North Carolina at Chapel Hill , Lilongwe , Malawi.
Elizabeth Cromwellb Department of Epidemiology , University of North Carolina at Chapel Hill , Chapel Hill , USA.
Hannock Tweyac Lighthouse Trust , Lilongwe , Malawi.
Mina C Hosseinipoura UNC Project , University of North Carolina at Chapel Hill , Lilongwe , Malawi.
Irving Hoffmana UNC Project , University of North Carolina at Chapel Hill , Lilongwe , Malawi.
William C Millerb Department of Epidemiology , University of North Carolina at Chapel Hill , Chapel Hill , USA.
Nora E Rosenberga UNC Project , University of North Carolina at Chapel Hill , Lilongwe , Malawi.
University of North Carolina at Chapel Hill · USLighthouse Trust · MW

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Option B+: ART Safety and Durability during First and Subsequent PregnanciesR01HD080485 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HOSSEINIPOUR, MINA CHRISTINE · 2014 to 2019
$3.9M
Developing and Assessing a Male Engagement Intervention for Option B+ in MalawiR00MH104154 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROSENBERG, NORA · 2017 to 2019
$746k
Developing and Assessing a Male Engagement Intervention for Option B+ in MalawiK99MH104154 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROSENBERG, NORA · 2015 to 2016
$168k
FIC NIH HHS R25 TW009340NIAID NIH HHS P30 AI050410NICHD NIH HHS R01 HD080485NIMH NIH HHS K99 MH104154NIMH NIH HHS R00 MH104154
6 · The paper itself

Abstract

Malawi's Option B+ program provides all HIV-infected pregnant women free lifelong antiretroviral therapy (ART), but challenges remain regarding retention and ART adherence, potentially due to male partner barriers. We explored relationships between male partner involvement and Option B+ retention and adherence. In 2014, a randomized controlled trial in Malawi compared male recruitment strategies for couple HIV testing and counseling (cHTC) at an antenatal clinic. This secondary analysis was conducted among the entire cohort (N = 200) of women, irrespective of randomization status. We assessed whether cHTC attendance, early disclosure of HIV-positive status, and partner ART reminders were associated with retention and adherence at one month after starting treatment. Retention was defined as attending HIV clinic follow-up within one day of running out of pills. Adherence was defined as taking ≥95% of ARTs by pill count. We used binomial regression to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI). Median female age was 26 years. Most women (79%) were retained; of these, 68% were adherent. Receiving cHTC was associated with improved retention (aRR 1.33, 95% CI 1.12, 1.59). Receiving male partner ART reminders was weakly associated with retention (aRR 1.16, 95% CI 0.96, 1.39). Disclosure within one day was not associated with retention (aRR 1.08, 95% CI: 0.91, 1.28). Among those who were retained, these three behaviors were not associated with improved 95% adherence. CHTC could play an important role in improving Option B+ retention. Increasing cHTC participation and enhancing adherence-related messages within cHTC are important.

Indexed as

CounselingPatient Acceptance of Health CareAdultAnti-HIV AgentsCohort StudiesDisclosureFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalLogistic ModelsMalawiMaleMass ScreeningMedication AdherenceOdds RatioAnti-HIV Agentsadherenceoption B+Partner involvementPMTCTretention

Identifiers

PMID28355926
PMCPMC6372085
OpenAlexW2599361848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.