ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2017
The diagnostic utility of patient-report and speech-language pathologists' ratings for detecting the early onset of bulbar symptoms due to ALS.
Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 87 citations in OpenAlex.
- Improving Perceptual Speech Ratings: The Effects of Auditory Training on Judgments of Dysarthric Speech.Journal of speech, language, and hearing research : JSLHR · 2023Trial
- Speech-based digital endpoints track ALS progression and align with standard clinical outcomes: evidence from the VRG50635 trial.Scientific reports · 2026Article
- A Cross-Language Study of Oral Diadochokinesis: Rates and Rhythm.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2026Article
- Differentiating upper- and lower motor neuron diseases using automated acoustic analysis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025Article
- A Preliminary Investigation of Acoustic Features for Remote Monitoring of Respiration in ALS.Muscle & nerve · 2025Article
- Exploring Speech Biosignatures for Traumatic Brain Injury and Neurodegeneration: Pilot Machine Learning Study.JMIR neurotechnology · 2025Article
- Listener effort measures clinically meaningful change of dysarthria in amyotrophic lateral sclerosis.Brain communications · 2025Article
- Access for ALL in ALS: A large-scale, inclusive, collaborative consortium to unlock the molecular and genetic mechanisms of amyotrophic lateral sclerosis.Muscle & nerve · 2024Review
- Multimodal Technologies for Remote Assessment of Neurological and Mental Health.Journal of speech, language, and hearing research : JSLHR · 2024Review
- Voice Assessment in Patients with Amyotrophic Lateral Sclerosis: An Exploratory Study on Associations with Bulbar and Respiratory Function.Brain sciences · 2024Article
- Multimodal speech biomarkers for remote monitoring of ALS disease progression.Computers in biology and medicine · 2024Article
- The relationship of rate and pause features to the communicative participation of people living with ALS.Muscle & nerve · 2024Article
- Multimodal Speech Biomarkers for Remote Monitoring of ALS Disease Progression.medRxiv : the preprint server for health sciences · 2024Article
- Speech timing and monosyllabic diadochokinesis measures in the assessment of amyotrophic lateral sclerosis in Canadian French.International journal of speech-language pathology · 2024Article
- Detecting bulbar amyotrophic lateral sclerosis (ALS) using automatic acoustic analysis.Biomedical engineering online · 2024Article
- Automatic detection of ALS from single-trial MEG signals during speech tasks: a pilot study.Frontiers in psychology · 2024Article
- Improving Dysarthric Speech Segmentation With Emulated and Synthetic Augmentation.IEEE journal of translational engineering in health and medicine · 2024Article
- Acoustic Voice Analysis as a Useful Tool to Discriminate Different ALS Phenotypes.Biomedicines · 2023Article
- 3D Video Tracking Technology in the Assessment of Orofacial Impairments in Neurological Disease: Clinical Validation.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Measuring Articulatory Patterns in Amyotrophic Lateral Sclerosis Using a Data-Driven Articulatory Consonant Distinctiveness Space Approach.Journal of speech, language, and hearing research : JSLHR · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThis study aimed to determine the diagnostic utility of clinician speech ratings and patient self-report for detecting early bulbar changes associated with amyotrophic lateral sclerosis (ALS), compared to instrumentation-based speech measures.
methodsThirty-six individuals with ALS and 17 healthy control participants were included. Patients' awareness of early bulbar motor involvement was assessed using self-reported scores on the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R). Clinicians' detection of early bulbar motor involvement was assessed through perceptual speech ratings by two experienced speech-language pathologists. Participants with ALS were grouped as 'bulbar pre-symptomatic' or 'bulbar symptomatic' based on self-report and clinician ratings, and compared to healthy controls on six instrumentation-based speech measures. ROC analysis was used to compare the sensitivity and specificity of perceptual and instrumentation-based measures for detecting bulbar changes in pre-symptomatic individuals.
resultsEarly bulbar changes that were documented using instrumentation-based measures were undetected by both patients and clinicians. ROC analyses indicated that instrumentation-based measures outperformed clinicians' scaled severity ratings, and that percent pause time was the best measure for differentiating healthy controls from bulbar pre-symptomatic individuals with ALS.
conclusionsFindings suggested that instrumentation-based measures of speech may be necessary for early detection of bulbar changes due to ALS.
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Registered trials
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