Evidence map›Paper›PMID 28355613›Full record

ArticleJournal of travel medicine2017

Clostridium difficile infection in returning travellers.

A Michal Stevens, Douglas H Esposito, Rhett J Stoney, Davidson H Hamer, Jose Flores-Figueroa, Emmanuel Bottieau, Bradley A Connor, Effrossyni Gkrania-Klotsas, Abraham Goorhuis, Noreen A Hynes and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of travel medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. GeoSentinel: past, present and future†.Journal of travel medicine · 2020
    Review
  3. Probiotics in Medicine: A Long Debate.Frontiers in immunology · 2020
    Review
  4. Yellow Fever in Travelers.Current infectious disease reports · 2019
    Review
  5. Evaluation of the sick returned traveler.Seminars in diagnostic pathology · 2019
    Review
  6. Article
  7. Travelers' Diarrhea: A Clinical Review.Recent patents on inflammation & allergy drug discovery · 2019
    Review
  8. Article
  9. Article
  10. Fever in the Returning Traveler.Infectious disease clinics of North America · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 8 countries.

A Michal StevensInternational Travel Clinic, Division of Infectious Diseases, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT, USA.
Douglas H EspositoTravelers' Health Branch, Division of Global Migration and Quarantine, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Rhett J StoneyTravelers' Health Branch, Division of Global Migration and Quarantine, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Davidson H HamerDepartment of Global Health, and Center for Global Health and Development, Boston University School of Public Health (BUSPH), Boston, MA, USA.
Jose Flores-FigueroaJM Research, Cuernavaca, Mexico.
Emmanuel BottieauDepartment of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Bradley A ConnorWeill Medical College of Cornell University, New York, NY, USA.
Effrossyni Gkrania-KlotsasDepartment of Infectious Diseases, Cambridge University Hospitals, Cambridge, UK.
Abraham GoorhuisCenter of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Noreen A HynesGeographic Medicine Center, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Michael LibmanJ.D. MacLean Centre for Tropical Diseases, McGill University, Montreal, Québec, QC, Canada.
Rogelio Lopez-VelezNational Referral Unit for Tropical Diseases, Department of Infectious Diseases, Ramón y Cajal University Hospital, Madrid, Spain.
Anne E McCarthyTropical Medicine and International Health Clinic, Division of Infectious Diseases, Ottawa Hospital and the University of Ottawa, Ottawa, ON, Canada.
Frank von SonnenburgDepartment of Infectious Diseases and Tropical Medicine, Ludwig-Maximilian's University of Munich, Munich, Germany.
Eli SchwartzCenter for Geographic Medicine, Department of Medicine C, Sheba Medical Center, Tel Hashomer, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Perry J J van GenderenInstitute for Tropical Diseases, Harbor Hospital, Rotterdam, The Netherlands.
L Scott BensonInternational Travel Clinic, Division of Infectious Diseases, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT, USA.
Daniel T LeungInternational Travel Clinic, Division of Infectious Diseases, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT, USA.
GeoSentinel Surveillance Network
University of Utah · USCenters for Disease Control and Prevention · USBoston University · USCornell University · USInstituut voor Tropische Geneeskunde · BEJohns Hopkins University · USLudwig-Maximilians-Universität München · DEMcGill University · CAMedical Research Council · GBTel Aviv University · ILUniversidad Del Valle De Cuernavaca · MXUniversity of Amsterdam · NLUniversity of Ottawa · CA

Funding

Intramural CDC HHS CC999999Medical Research Council G0701652NCEZID CDC HHS U50 CK000189
6 · The paper itself

Abstract

Background: There is increasing recognition of the contribution of community-acquired cases to the global burden of Clostridium difficile infection (CDI). The epidemiology of CDI among international travellers is poorly understood, and factors associated with international travel, such as antibiotic use and changes in gut microbiota, could potentially put travellers at higher risk. Methods: We summarized demographic, travel-associated and geographic characteristics of travellers with CDI in the GeoSentinel database from 1997 to 2015. We also surveyed GeoSentinel sites to compare various testing indications, approaches, and diagnostic modalities. Results: We identified 260 GeoSentinel records, including 187 that satisfied criteria for analysis (confirmed cases in non-immigrant travellers aged >2 years, seen <12 weeks post-travel). CDI was reported in all age groups and in travellers to all world regions; the largest proportions of cases having destinations in Asia (31%), Central/South America or the Caribbean (30%) and Africa (24%). Our site survey revealed substantial heterogeneity of testing approaches between sites; the most commonly used test was the C. difficile toxin gene PCR. Conclusions: CDI is encountered in returning international travellers, although there is considerable variability in testing practices. These data underscore the importance of awareness of C. difficile as a potential cause of travel-associated diarrhoea.

Indexed as

Travel MedicineAdolescentAdultAgedAged, 80 and overChildChild, PreschoolClostridioides difficileClostridium InfectionsFemaleGlobal HealthHumansMaleMiddle AgedPopulation SurveillanceYoung AdultClostridium difficilediarrhoeatravellers

Identifiers

PMID28355613
PMCPMC5697897
OpenAlexW2765149458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.