ArticleDevelopmental neuroscience2017
New Wavelet Neurovascular Bundle for Bedside Evaluation of Cerebral Autoregulation and Neurovascular Coupling in Newborns with Hypoxic-Ischemic Encephalopathy.
Article in Developmental neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Data-driven wavelet coherence approach to assess neurovascular coupling in neonatal hypoxic-ischemic encephalopathy.Neurophotonics · 2026Article
- Ultrafast ultrasound imaging reveals altered cerebral blood flow in newborn rats with hypoxic-ischemic encephalopathy.Pediatric research · 2026Article
- Real-time monitoring of wavelet-based neurovascular coupling in neonates with hypoxic ischemic encephalopathy using an hourly time window.Neurophotonics · 2025Article
- Evaluation of neurovascular coupling during neuroprotective therapies: A single site HEAL ancillary study.Early human development · 2023Article
- Reduced-order modeling and analysis of dynamic cerebral autoregulation via diffusion maps.Physiological measurement · 2023Article
- Technical feasibility of multimodal imaging in neonatal hypoxic-ischemic encephalopathy from an ovine model to a human case series.Frontiers in pediatrics · 2023Article
- Optimal neuromonitoring techniques in neonates with hypoxic ischemic encephalopathy.Frontiers in pediatrics · 2023Review
- Functional connectivity for the language network in the developing brain: 30 weeks of gestation to 30 months of age.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The INfoMATAS project: Methods for assessing cerebral autoregulation in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- The Utility of Cerebral Autoregulation Indices in Detecting Severe Brain Injury Varies by Cooling Treatment Phase in Neonates with Hypoxic-Ischemic Encephalopathy.Developmental neuroscience · 2022Observational
- Bedside and laboratory neuromonitoring in neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021Review
- Exploratory Assessment of the Relationship Between Hemoglobin Volume Phase Index, Magnetic Resonance Imaging, and Functional Outcome in Neonates with Hypoxic-Ischemic Encephalopathy.Neurocritical care · 2021Article
- Neonatal NIRS monitoring: recommendations for data capture and review of analytics.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future.Pediatric research · 2021Review
- Wavelet-based neurovascular coupling can predict brain abnormalities in neonatal encephalopathy.NeuroImage. Clinical · 2021Article
- Cerebral Blood Flow Monitoring in High-Risk Fetal and Neonatal Populations.Frontiers in pediatrics · 2021Review
- Comparison of wavelet and correlation indices of cerebral autoregulation in a pediatric swine model of cardiac arrest.Scientific reports · 2020Article
- Resuscitating the Globally Ischemic Brain: TTM and Beyond.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Joint time-frequency analysis of dynamic cerebral autoregulation using generalized harmonic wavelets.Physiological measurement · 2020Article
- Cerebral Blood Flow Regulation in Pregnancy, Hypertension, and Hypertensive Disorders of Pregnancy.Brain sciences · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neonatal encephalopathy (NE) resulting from birth asphyxia constitutes a major global public health burden for millions of infants every year, and despite therapeutic hypothermia, half of these neonates have poor neurological outcomes. As new neuroprotective interventions are being studied in clinical trials, there is a critical need to establish physiological surrogate markers of therapeutic efficacy, to guide patient selection and/or to modify the therapeutic intervention. The challenge in the field of neonatal brain injury has been the difficulty of clinically discerning NE severity within the short therapeutic window after birth or of analyzing the dynamic aspects of the cerebral circulation in sick NE newborns. To address this roadblock, we have recently developed a new "wavelet neurovascular bundle" analytical system that can measure cerebral autoregulation (CA) and neurovascular coupling (NVC) at multiple time scales under dynamic, nonstationary clinical conditions. This wavelet analysis may allow noninvasive quantification at the bedside of (1) CA (combining metrics of blood pressure and cerebral near-infrared spectroscopy, NIRS) and (2) NVC (combining metrics obtained from NIRS and EEG) in newborns with encephalopathy without mathematical assumptions of linear and stationary systems. In this concept paper, we present case examples of NE using the proposed physiological wavelet metrics of CA and NVC. The new approach, once validated in large NE studies, has the potential to optimize the selection of candidates for therapeutic decision-making, and the prediction of neurocognitive outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.